| Literature DB >> 203257 |
Abstract
The tissue changes in osteogenesis imperfecta apparently lie in the collagen and in the glycosaminoglycans. The collagen shows structural development disturbance and incomplete calcification. The tissue glycosaminoglycans are increased. The basis probably lies in a disturbed ATP metabolism (Solomons and Millar, 1973). An increased pyrophosphate concentration explains the decreased calcification and the structural changes. The increased osteolysis could be explained by increased quantities of cAMP.Entities:
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Year: 1977 PMID： 203257 DOI： 10.1007/bf00414994
Source DB: PubMed Journal: Arch Orthop Unfallchir ISSN： 0003-9330