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Literature DB >> 20309759

Weighted gene coexpression network analysis: state of the art.

Wei Zhao¹, Peter Langfelder, Tova Fuller, Jun Dong, Ai Li, Steve Hovarth.

Abstract

Weighted gene coexpression network analysis (WGCNA) has been applied to many important studies since its introduction in 2005. WGCNA can be used as a data exploratory tool or as a gene screening method; WGCNA can also be used as a tool to generate testable hypothesis for validation in independent data sets. In this article, we review key concepts of WGCNA and some of its applications in gene expression analysis of oncology, brain function, and protein interaction data.

Mesh：

Substances：
RNA, Messenger

Year: 2010 PMID： 20309759 DOI： 10.1080/10543400903572753

Source DB: PubMed Journal: J Biopharm Stat ISSN： 1054-3406 Impact factor: 1.051

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Cited

129 in total

1. Gene networks and haloperidol-induced catalepsy.

Authors: O D Iancu; P Darakjian; B Malmanger; N A R Walter; S McWeeney; R Hitzemann
Journal: Genes Brain Behav Date: 2011-11-11 Impact factor: 3.449

2. Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury.

Authors: Emilie L Castranio; Anais Mounier; Cody M Wolfe; Kyong Nyon Nam; Nicholas F Fitz; Florent Letronne; Jonathan Schug; Radosveta Koldamova; Iliya Lefterov
Journal: Neurobiol Dis Date: 2017-05-11 Impact factor: 5.996

3. Habitual aerobic exercise and circulating proteomic patterns in healthy adults: relation to indicators of healthspan.

Authors: Jessica R Santos-Parker; Keli S Santos-Parker; Matthew B McQueen; Christopher R Martens; Douglas R Seals
Journal: J Appl Physiol (1985) Date: 2018-09-20

Review 4. Systems genetics: a novel approach to dissect the genetic basis of osteoporosis.

Authors: Charles R Farber
Journal: Curr Osteoporos Rep Date: 2012-09 Impact factor: 5.096

5. Voluntary wheel running reduces voluntary consumption of ethanol in mice: identification of candidate genes through striatal gene expression profiling.

Authors: T M Darlington; R D McCarthy; R J Cox; J Miyamoto-Ditmon; X Gallego; M A Ehringer
Journal: Genes Brain Behav Date: 2016-05-31 Impact factor: 3.449

Weighted gene coexpression network analysis: state of the art.

1. Gene networks and haloperidol-induced catalepsy.

2. Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury.

3. Habitual aerobic exercise and circulating proteomic patterns in healthy adults: relation to indicators of healthspan.

Review 4. Systems genetics: a novel approach to dissect the genetic basis of osteoporosis.

5. Voluntary wheel running reduces voluntary consumption of ethanol in mice: identification of candidate genes through striatal gene expression profiling.

6. FoxP2 isoforms delineate spatiotemporal transcriptional networks for vocal learning in the zebra finch.

7. Integrated approach reveals diet, APOE genotype and sex affect immune response in APP mice.

Review 8. Modeling the diagnostic criteria for alcohol dependence with genetic animal models.

9. Transcriptional Changes in the Mouse Retina after Ocular Blast Injury: A Role for the Immune System.

Review 10. Introduction to sequencing the brain transcriptome.