Literature DB >> 20307565

Mitochondrial DNA alterations and reduced mitochondrial function in aging.

Sadie L Hebert1, Ian R Lanza, K Sreekumaran Nair.   

Abstract

Oxidative damage to mitochondrial DNA increases with aging. This damage has the potential to affect mitochondrial DNA replication and transcription which could alter the abundance or functionality of mitochondrial proteins. This review describes mitochondrial DNA alterations and changes in mitochondrial function that occur with aging. Age-related alterations in mitochondrial DNA as a possible contributor to the reduction in mitochondrial function are discussed. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

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Year:  2010        PMID： 20307565      PMCID： PMC2910809          DOI： 10.1016/j.mad.2010.03.007

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN： 0047-6374            Impact factor:   5.432


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