Literature DB >> 20307100

Encapsulation of a radiolabeled cluster inside a fullerene cage, (177)Lu(x)Lu((3-x))N@C(80): an interleukin-13-conjugated radiolabeled metallofullerene platform.

Michael D Shultz1, James C Duchamp, John D Wilson, Chun-Ying Shu, Jiechao Ge, Jianyuan Zhang, Harry W Gibson, Helen L Fillmore, Jerry I Hirsch, Harry C Dorn, Panos P Fatouros.   

Abstract

In this communication, we describe the successful encapsulation of (177)Lu into the endohedral metallofullerene (177)Lu(x)Lu(3-x)N@C(80) (x = 1-3) starting with (177)LuCl(3) in a modified quartz Kraschmer-Huffman electric generator. We demonstrate that the (177)Lu (beta-emitter) in this fullerene cage is not significantly released for a period of up to at least one-half-life (6.7 days). We also demonstrate that this agent can be conjugated with an interleukin-13 peptide that is designed to target an overexpressed receptor in glioblastoma multiforme tumors. This nanoparticle delivery platform provides flexibility for a wide range of radiotherapeutic and radiodiagnostic multimodal applications.

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Year:  2010        PMID： 20307100      PMCID： PMC2875150          DOI： 10.1021/ja9093617

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  13 in total

1.  Therapeutic radiopharmaceuticals.

Authors:  W A Volkert; T J Hoffman
Journal:  Chem Rev       Date:  1999-09-08       Impact factor: 60.622

2.  In vitro and in vivo imaging studies of a new endohedral metallofullerene nanoparticle.

Authors:  Panos P Fatouros; Frank D Corwin; Zhi-Jian Chen; William C Broaddus; James L Tatum; Birgit Kettenmann; Zhongxin Ge; Harry W Gibson; Jennifer L Russ; Anthony P Leonard; James C Duchamp; Harry C Dorn
Journal:  Radiology       Date:  2006-07-12       Impact factor: 11.105

3.  Purification of endohedral trimetallic nitride fullerenes in a single, facile step.

Authors:  Zhongxin Ge; James C Duchamp; Ting Cai; Harry W Gibson; Harry C Dorn
Journal:  J Am Chem Soc       Date:  2005-11-23       Impact factor: 15.419

4.  Individual voxelwise dosimetry of targeted 90Y-labelled substance P radiotherapy for malignant gliomas.

Authors:  Stefan Kneifel; Peter Bernhardt; Helena Uusijärvi; Stephan Good; Ludwig Plasswilm; Carlos Buitrago-Téllez; Jan Müller-Brand; Helmut Mäcke; Adrian Merlo
Journal:  Eur J Nucl Med Mol Imaging       Date:  2007-01-31       Impact factor: 9.236

5.  Facile preparation of a new gadofullerene-based magnetic resonance imaging contrast agent with high 1H relaxivity.

Authors:  Chunying Shu; Frank D Corwin; Jianfei Zhang; Zhijian Chen; Jonathan E Reid; Minghao Sun; Wei Xu; Jae Hyun Sim; Chunru Wang; Panos P Fatouros; Alan R Esker; Harry W Gibson; Harry C Dorn
Journal:  Bioconjug Chem       Date:  2009-06       Impact factor: 4.774

6.  (212)Pb@C(60) and its water-soluble derivatives: synthesis, stability, and suitability for radioimmunotherapy.

Authors:  Michael D Diener; John M Alford; Stephen J Kennel; Saed Mirzadeh
Journal:  J Am Chem Soc       Date:  2007-03-30       Impact factor: 15.419

7.  Interleukin 13 mutants of enhanced avidity toward the glioma-associated receptor, IL13Ralpha2.

Authors:  A B Madhankumar; Akiva Mintz; Waldemar Debinski
Journal:  Neoplasia       Date:  2004 Jan-Feb       Impact factor: 5.715

8.  IL-13Ralpha2 is a glioma-restricted receptor for interleukin-13.

Authors:  Akiva Mintz; Denise M Gibo; Becky Slagle-Webb; Neil D Christensen; Waldemar Debinski
Journal:  Neoplasia       Date:  2002 Sep-Oct       Impact factor: 5.715

Review 9.  Medicinal applications of fullerenes.

Authors:  Rania Bakry; Rainer M Vallant; Muhammad Najam-ul-Haq; Matthias Rainer; Zoltan Szabo; Christian W Huck; Günther K Bonn
Journal:  Int J Nanomedicine       Date:  2007

10.  Human glioma cells overexpress receptors for interleukin 13 and are extremely sensitive to a novel chimeric protein composed of interleukin 13 and pseudomonas exotoxin.

Authors:  W Debinski; N I Obiri; S K Powers; I Pastan; R K Puri
Journal:  Clin Cancer Res       Date:  1995-11       Impact factor: 13.801
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  17 in total

1.  Metallofullerene-based nanoplatform for brain tumor brachytherapy and longitudinal imaging in a murine orthotopic xenograft model.

Authors:  Michael D Shultz; John D Wilson; Christine E Fuller; Jianyuan Zhang; Harry C Dorn; Panos P Fatouros
Journal:  Radiology       Date:  2011-08-03       Impact factor: 11.105

Review 2.  Nanotechnology to augment immunotherapy for the treatment of glioblastoma multiforme.

Authors:  Nolan Ung; Isaac Yang
Journal:  J Neurooncol       Date:  2015-06-13       Impact factor: 4.130

3.  Efficient Uptake of 177 Lu-Porphyrin-PEG Nanocomplexes by Tumor Mitochondria for Multimodal-Imaging-Guided Combination Therapy.

Authors:  Bo Yu; Hao Wei; Qianjun He; Carolina A Ferreira; Christopher J Kutyreff; Dalong Ni; Zachary T Rosenkrans; Liang Cheng; Faquan Yu; Jonathan W Engle; Xiaoli Lan; Weibo Cai
Journal:  Angew Chem Int Ed Engl       Date:  2017-11-30       Impact factor: 15.336

4.  In vitro and in vivo studies of single-walled carbon nanohorns with encapsulated metallofullerenes and exohedrally functionalized quantum dots.

Authors:  Jianfei Zhang; Jiechao Ge; Michael D Shultz; Eunna Chung; Gurpreet Singh; Chunying Shu; Panos P Fatouros; Scott C Henderson; Frank D Corwin; David B Geohegan; Alex A Puretzky; Christopher M Rouleau; Karren More; Christopher Rylander; Marissa Nichole Rylander; Harry W Gibson; Harry C Dorn
Journal:  Nano Lett       Date:  2010-08-11       Impact factor: 11.189

5.  Trimetallic Nitride Endohedral Fullerenes Carboxyl-Gd3N@C80: A New Theranostic Agent for Combating Oxidative Stress and Resolving Inflammation.

Authors:  Tinghui Li; Li Xiao; Jiezuan Yang; Mengmeng Ding; Zhiguo Zhou; Leslie LaConte; Li Jin; Harry C Dorn; Xudong Li
Journal:  ACS Appl Mater Interfaces       Date:  2017-05-19       Impact factor: 9.229

6.  Magnetic resonance molecular imaging for non-invasive precision cancer diagnosis.

Authors:  Zheng-Rong Lu
Journal:  Curr Opin Biomed Eng       Date:  2017-11-16

7.  Metallofullerene-nanoplatform-delivered interstitial brachytherapy improved survival in a murine model of glioblastoma multiforme.

Authors:  John D Wilson; William C Broaddus; Harry C Dorn; Panos P Fatouros; Charles E Chalfant; Michael D Shultz
Journal:  Bioconjug Chem       Date:  2012-08-21       Impact factor: 4.774

Review 8.  Multifunctional nanoparticles for brain tumor imaging and therapy.

Authors:  Yu Cheng; Ramin A Morshed; Brenda Auffinger; Alex L Tobias; Maciej S Lesniak
Journal:  Adv Drug Deliv Rev       Date:  2013-09-20       Impact factor: 15.470

9.  Emerging role of radiolabeled nanoparticles as an effective diagnostic technique.

Authors:  Andréluís Branco de Barros; Andrew Tsourkas; Babak Saboury; Valbert Nascimento Cardoso; Abass Alavi
Journal:  EJNMMI Res       Date:  2012-07-18       Impact factor: 3.138

10.  Defect induced electronic structure of uranofullerene.

Authors:  Xing Dai; Cheng Cheng; Wei Zhang; Minsi Xin; Ping Huai; Ruiqin Zhang; Zhigang Wang
Journal:  Sci Rep       Date:  2013       Impact factor: 4.379
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