Literature DB >> 28516768

Trimetallic Nitride Endohedral Fullerenes Carboxyl-Gd3N@C80: A New Theranostic Agent for Combating Oxidative Stress and Resolving Inflammation.

Tinghui Li1, Li Xiao2, Jiezuan Yang2, Mengmeng Ding2, Zhiguo Zhou3, Leslie LaConte4, Li Jin2, Harry C Dorn1,4, Xudong Li2.   

Abstract

Antioxidative and anti-inflammatory effects of trimetallic nitride endohedral fullerenes carboxyl-Gd3N@C80, a newly developed magnetic resonance imaging (MRI) contrast agent, were investigated. All hydrochalarone and carboxyl-functionalized fullerenes showed effective radical (hydroxyl and superoxide anion) scavenging, whereas the carboxyl-Gd3N@C80 more efficiently attenuated lipopolysaccharide (LPS) induced oxidative stress in macrophages. Carboxyl-Gd3N@C80 also suppressed LPS-elicited mRNA expression of pro-inflammatory inducible nitric oxide synthase and tumor necrosis factor-alpha, and upregulated antioxidative enzyme axis Nrf2 and heme oxygenase-1, possibly via ERK but not AKT signaling pathways. Therefore, carboxyl-Gd3N@C80 held a great promise in becoming a novel theranostic nanoplatform for simultaneously deliver MRI contrast and therapeutic functions to inflammation-related diseases.

Entities:  

Keywords:  AKT; ERK; inflammation; macrophage; oxidative stress; theranostic; trimetallic nitride endohedral fullerenes

Mesh：

Substances：

Year:  2017        PMID： 28516768      PMCID： PMC5670744          DOI： 10.1021/acsami.7b04718

Source DB:  PubMed          Journal:  ACS Appl Mater Interfaces        ISSN： 1944-8244            Impact factor:   9.229


  26 in total

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Authors:  Jiangxue Wang; Chunying Chen; Bai Li; Hongwei Yu; Yuliang Zhao; Jin Sun; Yufeng Li; Gengmei Xing; Hui Yuan; Jun Tang; Zhen Chen; Huan Meng; Yuxi Gao; Chang Ye; Zhifang Chai; Chuanfeng Zhu; Baocheng Ma; Xiaohong Fang; Lijun Wan
Journal:  Biochem Pharmacol       Date:  2006-01-24       Impact factor: 5.858

2.  The heme oxygenase 1 inducer (CoPP) protects human cardiac stem cells against apoptosis through activation of the extracellular signal-regulated kinase (ERK)/NRF2 signaling pathway and cytokine release.

Authors:  Chuanxi Cai; Lei Teng; Duc Vu; Jia-Qiang He; Yiru Guo; Qianghong Li; Xian-Liang Tang; Gregg Rokosh; Aruni Bhatnagar; Roberto Bolli
Journal:  J Biol Chem       Date:  2012-08-09       Impact factor: 5.157

3.  Gd@C82 metallofullerenes for neutron capture therapy-fullerene solubilization by poly(ethylene glycol)-block-poly(2-(N, N-diethylamino)ethyl methacrylate) and resultant efficacy in vitro.

Authors:  Yukichi Horiguchi; Shinpei Kudo; Yukio Nagasaki
Journal:  Sci Technol Adv Mater       Date:  2011-07-07       Impact factor: 8.090

Review 4.  Biomedical Applications of Metal-Encapsulated Fullerene Nanoparticles.

Authors:  Tinghui Li; Harry C Dorn
Journal:  Small       Date:  2016-12-27       Impact factor: 13.281

5.  Inhibition of LPS-stimulated pathways in macrophages by the flavonoid luteolin.

Authors:  Angeliki Xagorari; Charis Roussos; Andreas Papapetropoulos
Journal:  Br J Pharmacol       Date:  2002-08       Impact factor: 8.739

6.  A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties.

Authors:  Sameh S Ali; Joshua I Hardt; Kevin L Quick; Jeong Sook Kim-Han; Bernard F Erlanger; Ting-Ting Huang; Charles J Epstein; Laura L Dugan
Journal:  Free Radic Biol Med       Date:  2004-10-15       Impact factor: 7.376

7.  Gd@C82-(ethylenediamine)8 Nanoparticle: A New High-Efficiency Water-Soluble ROS Scavenger.

Authors:  Jie Li; Mirong Guan; Taishan Wang; Mingming Zhen; Fuwen Zhao; Chunying Shu; Chunru Wang
Journal:  ACS Appl Mater Interfaces       Date:  2016-09-22       Impact factor: 9.229

8.  Fullerol antagonizes dexamethasone-induced oxidative stress and adipogenesis while enhancing osteogenesis in a cloned bone marrow mesenchymal stem cell.

Authors:  Hongjian Liu; Xinlin Yang; Yi Zhang; Abhijit Dighe; Xudong Li; Quanjun Cui
Journal:  J Orthop Res       Date:  2012-01-03       Impact factor: 3.494

Review 9.  Oxidative stress in cancer and fibrosis: Opportunity for therapeutic intervention with antioxidant compounds, enzymes, and nanoparticles.

Authors:  Jingga Morry; Worapol Ngamcherdtrakul; Wassana Yantasee
Journal:  Redox Biol       Date:  2016-12-16       Impact factor: 11.799

10.  The scavenging of reactive oxygen species and the potential for cell protection by functionalized fullerene materials.

Authors:  Jun-Jie Yin; Fang Lao; Peter P Fu; Wayne G Wamer; Yuliang Zhao; Paul C Wang; Yang Qiu; Baoyun Sun; Gengmei Xing; Jinquan Dong; Xing-Jie Liang; Chunying Chen
Journal:  Biomaterials       Date:  2008-11-04       Impact factor: 12.479
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  4 in total

1.  Microfluidic Disc-on-a-Chip Device for Mouse Intervertebral Disc-Pitching a Next-Generation Research Platform To Study Disc Degeneration.

Authors:  Jun Dai; Yuan Xing; Li Xiao; Jingyi Li; Ruofan Cao; Yi He; Huang Fang; Ammasi Periasamy; Jose Oberhozler; Li Jin; James P Landers; Yong Wang; Xudong Li
Journal:  ACS Biomater Sci Eng       Date:  2019-02-26

2.  A New Formyl Peptide Receptor-1 Antagonist Conjugated Fullerene Nanoparticle for Targeted Treatment of Degenerative Disc Diseases.

Authors:  Li Xiao; Rong Huang; Yi Zhang; Tinghui Li; Jun Dai; Naga Nannapuneni; Timothy R Chastanet; Matthew Chen; Francis H Shen; Li Jin; Harry C Dorn; Xudong Li
Journal:  ACS Appl Mater Interfaces       Date:  2019-10-08       Impact factor: 9.229

Review 3.  Recent advances in nanomaterials for therapy and diagnosis for atherosclerosis.

Authors:  Jun Chen; Xixi Zhang; Reid Millican; Jennifer Sherwood; Sean Martin; Hanjoong Jo; Young-Sup Yoon; Brigitta C Brott; Ho-Wook Jun
Journal:  Adv Drug Deliv Rev       Date:  2021-01-09       Impact factor: 15.470

4.  Studies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenes.

Authors:  Geraldine Magnin; Philippe Bissel; Roberto McAlister Council-Troche; Zhiguo Zhou; Marion Ehrich
Journal:  ACS Omega       Date:  2019-10-28
  4 in total

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