Literature DB >> 20306505

Bioorthogonal turn-on probes for imaging small molecules inside living cells.

Neal K Devaraj1, Scott Hilderbrand, Rabi Upadhyay, Ralph Mazitschek, Ralph Weissleder.   

Abstract

Glowing tags: a series of activatable ("turn-on") tetrazine-conjugated fluorescent probes was developed, which react rapidly in an inverse-electron-demand [4+2] cycloaddition with strained dienophiles such as trans-cyclooctene, thereby strongly increasing the fluorescence intensity. The novel turn-on probes were applied for intracellular live-cell imaging of a microtubuli-binding trans-cyclooctene modified taxol.
Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2010        PMID： 20306505      PMCID： PMC3433403          DOI： 10.1002/anie.200906120

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  35 in total

1.  Hyperconjugative and inductive perturbations in poly(p-phenylene vinylenes).

Authors:  Youngmi Kim; Zhengguo Zhu; Timothy M Swager
Journal:  J Am Chem Soc       Date:  2004-01-21       Impact factor: 15.419

2.  A fluorogenic probe for the copper(I)-catalyzed azide-alkyne ligation reaction: modulation of the fluorescence emission via 3(n,pi)-1(pi,pi) inversion.

Authors:  Zhen Zhou; Christoph J Fahrni
Journal:  J Am Chem Soc       Date:  2004-07-28       Impact factor: 15.419

Review 3.  Chemistry in living systems.

Authors:  Jennifer A Prescher; Carolyn R Bertozzi
Journal:  Nat Chem Biol       Date:  2005-06       Impact factor: 15.040

4.  A FRET-based fluorogenic phosphine for live-cell imaging with the Staudinger ligation.

Authors:  Matthew J Hangauer; Carolyn R Bertozzi
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

5.  Microtubule assembly in the absence of added nucleotides.

Authors:  M L Shelanski; F Gaskin; C R Cantor
Journal:  Proc Natl Acad Sci U S A       Date:  1973-03       Impact factor: 11.205

6.  Preparation and biological activity of taxol acetates.

Authors:  W Mellado; N F Magri; D G Kingston; R Garcia-Arenas; G A Orr; S B Horwitz
Journal:  Biochem Biophys Res Commun       Date:  1984-10-30       Impact factor: 3.575

7.  Taxol assembles tubulin in the absence of exogenous guanosine 5'-triphosphate or microtubule-associated proteins.

Authors:  P B Schiff; S B Horwitz
Journal:  Biochemistry       Date:  1981-05-26       Impact factor: 3.162

8.  Tetrazine-based cycloadditions: application to pretargeted live cell imaging.

Authors:  Neal K Devaraj; Ralph Weissleder; Scott A Hilderbrand
Journal:  Bioconjug Chem       Date:  2008-12       Impact factor: 4.774

9.  Fast and sensitive pretargeted labeling of cancer cells through a tetrazine/trans-cyclooctene cycloaddition.

Authors:  Neal K Devaraj; Rabi Upadhyay; Jered B Haun; Scott A Hilderbrand; Ralph Weissleder
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

Review 10.  Taxol: a novel investigational antimicrotubule agent.

Authors:  E K Rowinsky; L A Cazenave; R C Donehower
Journal:  J Natl Cancer Inst       Date:  1990-08-01       Impact factor: 13.506
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  113 in total

1.  Bioorthogonal reaction pairs enable simultaneous, selective, multi-target imaging.

Authors:  Mark R Karver; Ralph Weissleder; Scott A Hilderbrand
Journal:  Angew Chem Int Ed Engl       Date:  2011-12-12       Impact factor: 15.336

2.  Synthesis and evaluation of a series of 1,2,4,5-tetrazines for bioorthogonal conjugation.

Authors:  Mark R Karver; Ralph Weissleder; Scott A Hilderbrand
Journal:  Bioconjug Chem       Date:  2011-10-24       Impact factor: 4.774

3.  Bioorthogonal imaging of aurora kinase A in live cells.

Authors:  Katherine S Yang; Ghyslain Budin; Thomas Reiner; Claudio Vinegoni; Ralph Weissleder
Journal:  Angew Chem Int Ed Engl       Date:  2012-05-29       Impact factor: 15.336

Review 4.  Recent Developments in Magnetic Diagnostic Systems.

Authors:  Hakho Lee; Tae-Hyun Shin; Jinwoo Cheon; Ralph Weissleder
Journal:  Chem Rev       Date:  2015-08-10       Impact factor: 60.622

5.  Divergent Synthesis of Monosubstituted and Unsymmetrical 3,6-Disubstituted Tetrazines from Carboxylic Ester Precursors.

Authors:  Yixin Xie; Yinzhi Fang; Zhen Huang; Amanda M Tallon; Christopher W Am Ende; Joseph M Fox
Journal:  Angew Chem Int Ed Engl       Date:  2020-08-07       Impact factor: 15.336

6.  A Toxic RNA Templates the Synthesis of Its Own Fluorogenic Inhibitor by Using a Bio-orthogonal Tetrazine Ligation in Cells and Tissues.

Authors:  Alicia J Angelbello; Matthew D Disney
Journal:  ACS Chem Biol       Date:  2020-06-17       Impact factor: 5.100

Review 7.  Expanding room for tetrazine ligations in the in vivo chemistry toolbox.

Authors:  Jolita Sečkutė; Neal K Devaraj
Journal:  Curr Opin Chem Biol       Date:  2013-09-07       Impact factor: 8.822

8.  Genetically encoded tetrazine amino acid directs rapid site-specific in vivo bioorthogonal ligation with trans-cyclooctenes.

Authors:  Jason L Seitchik; Jennifer C Peeler; Michael T Taylor; Melissa L Blackman; Timothy W Rhoads; Richard B Cooley; Christian Refakis; Joseph M Fox; Ryan A Mehl
Journal:  J Am Chem Soc       Date:  2012-02-01       Impact factor: 15.419

9.  A fluorogenic probe for the catalyst-free detection of azide-tagged molecules.

Authors:  Frédéric Friscourt; Christoph J Fahrni; Geert-Jan Boons
Journal:  J Am Chem Soc       Date:  2012-11-02       Impact factor: 15.419

10.  NLOphoric 3,6-di(substituted quinoxalin) Carbazoles - Synthesis, Photophysical Properties and DFT Studies.

Authors:  Rahul D Telore; Amol G Jadhav; Nagaiyan Sekar
Journal:  J Fluoresc       Date:  2017-04-22       Impact factor: 2.217
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