PURPOSE: To investigate whether there is familial aggregation of diabetic retinopathy (DR) among type 2 diabetes mellitus (T2DM) patients in Chongqing, the municipality in southwest China. METHODS: From December 2004 to December 2006, 167 T2DM families with at least 2 diabetic siblings were investigated. In all 414 subjects, the sibling with the longest duration of diabetes was defined as the proband. The occurrence of retinopathy was compared between the siblings of probands with and without retinopathy. DR risk factors of the siblings of probands were studied by multiple logistic regression analysis. RESULTS: DR was diagnosed in 7.1% of the siblings of the probands without DR and in 29.7% of the siblings of the probands with DR. The difference reached statistical significance in probands with DR and probands without DR (p<0.0001). Nonesterified fatty acid (NEFA) was a risk factor for DR (odds ratio = 2.108, 95% confidence interval 1.077-4.127). It appeared that regardless of probands with DR, siblings with history of smoking had less risk for developing DR than those with no history of smoking. CONCLUSIONS: Familial clustering of DR existed in the patients with T2DM in Chongqing, China. In DR siblings, NEFA is a risk factor of DR, while smoking may reduce DR occurrence.
PURPOSE: To investigate whether there is familial aggregation of diabetic retinopathy (DR) among type 2 diabetes mellitus (T2DM) patients in Chongqing, the municipality in southwest China. METHODS: From December 2004 to December 2006, 167 T2DM families with at least 2 diabetic siblings were investigated. In all 414 subjects, the sibling with the longest duration of diabetes was defined as the proband. The occurrence of retinopathy was compared between the siblings of probands with and without retinopathy. DR risk factors of the siblings of probands were studied by multiple logistic regression analysis. RESULTS: DR was diagnosed in 7.1% of the siblings of the probands without DR and in 29.7% of the siblings of the probands with DR. The difference reached statistical significance in probands with DR and probands without DR (p<0.0001). Nonesterified fatty acid (NEFA) was a risk factor for DR (odds ratio = 2.108, 95% confidence interval 1.077-4.127). It appeared that regardless of probands with DR, siblings with history of smoking had less risk for developing DR than those with no history of smoking. CONCLUSIONS: Familial clustering of DR existed in the patients with T2DM in Chongqing, China. In DR siblings, NEFA is a risk factor of DR, while smoking may reduce DR occurrence.
Authors: Weihua Meng; Kaanan P Shah; Samuela Pollack; Iiro Toppila; Harry L Hebert; Mark I McCarthy; Leif Groop; Emma Ahlqvist; Valeriya Lyssenko; Elisabet Agardh; Mark Daniell; Georgia Kaidonis; Jamie E Craig; Paul Mitchell; Gerald Liew; Annette Kifley; Jie Jin Wang; Mark W Christiansen; Richard A Jensen; Alan Penman; Heather A Hancock; Ching J Chen; Adolfo Correa; Jane Z Kuo; Xiaohui Li; Yii-der I Chen; Jerome I Rotter; Ronald Klein; Barbara Klein; Tien Y Wong; Andrew D Morris; Alexander S F Doney; Helen M Colhoun; Alkes L Price; Kathryn P Burdon; Per-Henrik Groop; Niina Sandholm; Michael A Grassi; Lucia Sobrin; Colin N A Palmer Journal: Acta Ophthalmol Date: 2018-09-04 Impact factor: 3.761