Z Shi1, B Yuan, L Qi, Y Dai, H Zuo, M Zhou. 1. Nutrition and Foodborne Disease Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China. zumins@vip.sina.com
Abstract
OBJECTIVE: To prospectively examine the associations between zinc intake, the zinc to heme iron ratio and the incidence of hyperglycemia in Chinese. METHODS: We followed 1056 healthy adults aged 20 and older from 2002 to 2007. Dietary data were collected using 3-day food record and food frequency questionnaire. Hyperglycemia was defined as fasting plasma glucose > 5.6 mmol/l. RESULTS: During the 5 years of follow-up, we documented 125 incident cases of hyperglycemia. Zinc intake alone was not associated with the risk of hyperglycemia. The zinc to heme iron ratio was inversely associated with the risk of hyperglycemia: odds ratios (OR, 95% CI) across increasing quartiles of the zinc to heme iron ratio were 1.00, 0.78(0.44-1.37), 0.40(0.19-0.83), and 0.21(0.08-0.54)(p for trend= 0.001). Adjustment for lifestyle covariates did not significantly change the associations. CONCLUSIONS: This cohort study suggests that the zinc to heme iron intake ratio was significantly associated with a decreased risk of hyperglycemia in Chinese adults.
OBJECTIVE: To prospectively examine the associations between zinc intake, the zinc to hemeiron ratio and the incidence of hyperglycemia in Chinese. METHODS: We followed 1056 healthy adults aged 20 and older from 2002 to 2007. Dietary data were collected using 3-day food record and food frequency questionnaire. Hyperglycemia was defined as fasting plasma glucose > 5.6 mmol/l. RESULTS: During the 5 years of follow-up, we documented 125 incident cases of hyperglycemia. Zinc intake alone was not associated with the risk of hyperglycemia. The zinc to hemeiron ratio was inversely associated with the risk of hyperglycemia: odds ratios (OR, 95% CI) across increasing quartiles of the zinc to hemeiron ratio were 1.00, 0.78(0.44-1.37), 0.40(0.19-0.83), and 0.21(0.08-0.54)(p for trend= 0.001). Adjustment for lifestyle covariates did not significantly change the associations. CONCLUSIONS: This cohort study suggests that the zinc to hemeiron intake ratio was significantly associated with a decreased risk of hyperglycemia in Chinese adults.
Authors: Stavroula Kanoni; Jennifer A Nettleton; Marie-France Hivert; Zheng Ye; Frank J A van Rooij; Dmitry Shungin; Emily Sonestedt; Julius S Ngwa; Mary K Wojczynski; Rozenn N Lemaitre; Stefan Gustafsson; Jennifer S Anderson; Toshiko Tanaka; George Hindy; Georgia Saylor; Frida Renstrom; Amanda J Bennett; Cornelia M van Duijn; Jose C Florez; Caroline S Fox; Albert Hofman; Ron C Hoogeveen; Denise K Houston; Frank B Hu; Paul F Jacques; Ingegerd Johansson; Lars Lind; Yongmei Liu; Nicola McKeown; Jose Ordovas; James S Pankow; Eric J G Sijbrands; Ann-Christine Syvänen; André G Uitterlinden; Mary Yannakoulia; M Carola Zillikens; Nick J Wareham; Inga Prokopenko; Stefania Bandinelli; Nita G Forouhi; L Adrienne Cupples; Ruth J Loos; Goran Hallmans; Josée Dupuis; Claudia Langenberg; Luigi Ferrucci; Stephen B Kritchevsky; Mark I McCarthy; Erik Ingelsson; Ingrid B Borecki; Jacqueline C M Witteman; Marju Orho-Melander; David S Siscovick; James B Meigs; Paul W Franks; George V Dedoussis Journal: Diabetes Date: 2011-08-01 Impact factor: 9.461
Authors: Jong Suk Park; Pengcheng Xun; Jing Li; Steve J Morris; David R Jacobs; Kiang Liu; Ka He Journal: Sci Rep Date: 2016-03-16 Impact factor: 4.379