BACKGROUND: Osteoarthritis is the most common joint disease of adults worldwide. Its incidence rises with age. Both intrinsic and extrinsic risk factors promote its development. In men aged 60 to 64, the right knee is more commonly affected; in women, the right and left knees are affected with nearly equal frequency. METHODS: The PubMed, Medline, Embase and Cochrane Library databases were selectively searched for current studies (up to September 2009; case reports excluded) on the epidemiology, etiology, diagnosis, staging, and treatment of osteoarthritis of the knee. The search terms were "gonarthrosis," "prevention," "conservative treatment," "joint preservation," "physical activity," "arthroscopy," "osteotomy," "braces," "orthoses," and "osteoarthritis knee joint." RESULTS AND CONCLUSION: Osteoarthritis is not yet a curable disease, and its pathogenesis remains unclear. The best treatment for osteoarthritis of the knee is prevention. The goal of therapy is to alleviate clinical manifestations. The therapeutic spectrum ranges from physiotherapy and orthopedic aids to pharmacotherapy and surgery.
BACKGROUND:Osteoarthritis is the most common joint disease of adults worldwide. Its incidence rises with age. Both intrinsic and extrinsic risk factors promote its development. In men aged 60 to 64, the right knee is more commonly affected; in women, the right and left knees are affected with nearly equal frequency. METHODS: The PubMed, Medline, Embase and Cochrane Library databases were selectively searched for current studies (up to September 2009; case reports excluded) on the epidemiology, etiology, diagnosis, staging, and treatment of osteoarthritis of the knee. The search terms were "gonarthrosis," "prevention," "conservative treatment," "joint preservation," "physical activity," "arthroscopy," "osteotomy," "braces," "orthoses," and "osteoarthritis knee joint." RESULTS AND CONCLUSION:Osteoarthritis is not yet a curable disease, and its pathogenesis remains unclear. The best treatment for osteoarthritis of the knee is prevention. The goal of therapy is to alleviate clinical manifestations. The therapeutic spectrum ranges from physiotherapy and orthopedic aids to pharmacotherapy and surgery.
Authors: A Kirkley; S Webster-Bogaert; R Litchfield; A Amendola; S MacDonald; R McCalden; P Fowler Journal: J Bone Joint Surg Am Date: 1999-04 Impact factor: 5.284
Authors: K M Jordan; N K Arden; M Doherty; B Bannwarth; J W J Bijlsma; P Dieppe; K Gunther; H Hauselmann; G Herrero-Beaumont; P Kaklamanis; S Lohmander; B Leeb; M Lequesne; B Mazieres; E Martin-Mola; K Pavelka; A Pendleton; L Punzi; U Serni; B Swoboda; G Verbruggen; I Zimmerman-Gorska; M Dougados Journal: Ann Rheum Dis Date: 2003-12 Impact factor: 19.103
Authors: A Pendleton; N Arden; M Dougados; M Doherty; B Bannwarth; J W Bijlsma; F Cluzeau; C Cooper; P A Dieppe; K P Günther; H J Hauselmann; G Herrero-Beaumont; P M Kaklamanis; B Leeb; M Lequesne; S Lohmander; B Mazieres; E M Mola; K Pavelka; U Serni; B Swoboda; A A Verbruggen; G Weseloh; I Zimmermann-Gorska Journal: Ann Rheum Dis Date: 2000-12 Impact factor: 19.103
Authors: László Hangody; Gábor K Ráthonyi; Zsófia Duska; Gábor Vásárhelyi; Péter Füles; László Módis Journal: J Bone Joint Surg Am Date: 2004-03 Impact factor: 5.284
Authors: R W Brouwer; T M Raaij van; S M A Bierma-Zeinstra; A P Verhagen; T S C Jakma; J A N Verhaar Journal: Cochrane Database Syst Rev Date: 2007-07-18