OBJECTIVE: We developed the Clinical Research Involvement Scales (CRIS) to assess the willingness to participate in a clinical trial. STUDY DESIGN AND SETTING: Diverse populations (N=919) aged 18 years or older from Atlanta, Georgia, were included in comprehensive testing of the 41-item CRIS instrument. The formative phase focused on item content for the new measures (n=54). Questionnaires from potential vaccine trial participants (n=865), collected at multiple time points, resulted in the evaluation of scale reliability and validity (i.e., attitudes, behavioral and normative beliefs, perceived social support for clinical research participation, social norm compliance, perceptions of the clinical research organization, and perceived relevance of the research endeavor). RESULTS: Qualitative testing revealed adequate comprehension and content validity of the initial item set. The subjective norms domain (n=3) initially exhibited poor internal consistency in pilot testing (Cronbach's alpha=0.525); yet, rewording of the items resulted in consistently stable measurement improvement (Cronbach's alpha=0.850). Each of the CRIS subscales demonstrated extremely high reliability, ranging from 0.734 to 0.918. Confirmatory factor analysis verified item-factor relationships and determined construct and convergent validity (root mean square error of approximation=0.068; comparative fit index=0.835). CONCLUSIONS: CRIS is a reliable instrument for measuring community attitudes toward participation in biomedical research studies. Results of this study support the use of these scales to recruit diverse populations to clinical trials. Copyright (c) 2010 Elsevier Inc. All rights reserved.
OBJECTIVE: We developed the Clinical Research Involvement Scales (CRIS) to assess the willingness to participate in a clinical trial. STUDY DESIGN AND SETTING: Diverse populations (N=919) aged 18 years or older from Atlanta, Georgia, were included in comprehensive testing of the 41-item CRIS instrument. The formative phase focused on item content for the new measures (n=54). Questionnaires from potential vaccine trial participants (n=865), collected at multiple time points, resulted in the evaluation of scale reliability and validity (i.e., attitudes, behavioral and normative beliefs, perceived social support for clinical research participation, social norm compliance, perceptions of the clinical research organization, and perceived relevance of the research endeavor). RESULTS: Qualitative testing revealed adequate comprehension and content validity of the initial item set. The subjective norms domain (n=3) initially exhibited poor internal consistency in pilot testing (Cronbach's alpha=0.525); yet, rewording of the items resulted in consistently stable measurement improvement (Cronbach's alpha=0.850). Each of the CRIS subscales demonstrated extremely high reliability, ranging from 0.734 to 0.918. Confirmatory factor analysis verified item-factor relationships and determined construct and convergent validity (root mean square error of approximation=0.068; comparative fit index=0.835). CONCLUSIONS: CRIS is a reliable instrument for measuring community attitudes toward participation in biomedical research studies. Results of this study support the use of these scales to recruit diverse populations to clinical trials. Copyright (c) 2010 Elsevier Inc. All rights reserved.
Authors: Ralph V Katz; S Steven Kegeles; Nancy R Kressin; B Lee Green; Min Qi Wang; Sherman A James; Stefanie Luise Russell; Cristina Claudio Journal: J Health Care Poor Underserved Date: 2006-11
Authors: Jennifer Cunningham; Kenneth A Wallston; Consuelo H Wilkins; Pamela C Hull; Stephania T Miller Journal: Clin Transl Sci Date: 2015-11-04 Impact factor: 4.689
Authors: Michael P Arnold; Michele Andrasik; Stewart Landers; Shelly Karuna; Matthew J Mimiaga; Steven Wakefield; Kenneth Mayer; Susan Buchbinder; Beryl A Koblin Journal: Am J Public Health Date: 2014-06-12 Impact factor: 9.308
Authors: Carrie A Sims; Joshua A Isserman; Daniel Holena; Latha Mary Sundaram; Nikolai Tolstoy; Sarah Greer; Seema Sonnad; Jose Pascual; Patrick Reilly Journal: J Trauma Acute Care Surg Date: 2013-01 Impact factor: 3.313
Authors: Danielle F Haley; Carol Golin; Wafaa El-Sadr; James P Hughes; Jing Wang; Malika Roman Isler; Sharon Mannheimer; Irene Kuo; Jonathan Lucas; Elizabeth DiNenno; Jessica Justman; Paula M Frew; Lynda Emel; Anne Rompalo; Sarah Polk; Adaora A Adimora; Lorenna Rodriquez; Lydia Soto-Torres; Sally Hodder Journal: J Womens Health (Larchmt) Date: 2014-04-17 Impact factor: 2.681
Authors: Danielle F Haley; Jonathan Lucas; Carol E Golin; Jing Wang; James P Hughes; Lynda Emel; Wafaa El-Sadr; Paula M Frew; Jessica Justman; Adaora A Adimora; Christopher Chauncey Watson; Sharon Mannheimer; Anne Rompalo; Lydia Soto-Torres; Zandraetta Tims-Cook; Yvonne Carter; Sally L Hodder Journal: AIDS Patient Care STDS Date: 2014-04 Impact factor: 5.078
Authors: Paula M Frew; Saad B Omer; Kimberly Parker; Marcus Bolton; Jay Schamel; Eve Shapiro; Lauren Owens; Diane Saint-Victor; Sahithi Boggavarapu; Nikia Braxton; Matthew Archibald; Ameeta S Kalokhe; Takeia Horton; Christin M Root; Vincent L Fenimore; Aaron M Anderson Journal: JMIR Res Protoc Date: 2015-06-02
Authors: Whitney C Sewell; Rupa R Patel; Stephanie Blankenship; Julia L Marcus; Douglas S Krakower; Phillip A Chan; Kimberly Parker Journal: AIDS Educ Prev Date: 2020-10