OBJECTIVE: To present pretreatment and post-treatment language data for a nonfluent aphasia patient who received 2 treatment modalities: (1) continuous positive airway pressure (CPAP) for his sleep apnea, starting 1-year poststroke; and (2) repetitive transcranial magnetic brain stimulation (TMS), starting 2 years poststroke. BACKGROUND: Language data were acquired beyond the spontaneous recovery period of 3 to 6 months poststroke onset. CPAP restores adequate oxygen flow throughout all stages of sleep, and may improve cognition. A series of slow, 1 Hz repetitive TMS treatments to suppress a posterior portion of right pars triangularis has been shown to improve phrase length and naming in chronic nonfluent aphasia. METHOD: The Boston Diagnostic Aphasia Examination and Boston Naming Test were administered pre-CPAP, and after 2 to 5 months of CPAP. These same tests were administered pre-TMS, and at 3 and 6 months post-TMS, and again 2.4 years later. RESULTS: Post-CPAP testing showed increased Phrase Length, Auditory Comprehension, and naming Animals and Tools/Implements (Boston Diagnostic Aphasia Examination). Testing at 3 and 6 months post-TMS showed significant increase in Phrase Length, Auditory Comprehension, and Boston Naming Test compared with pre-TMS. These gains were retained at 2.4 years post-TMS. CPAP use continued throughout. CONCLUSIONS: Physiologic treatment interventions may promote language recovery in chronic aphasia.
OBJECTIVE: To present pretreatment and post-treatment language data for a nonfluent aphasiapatient who received 2 treatment modalities: (1) continuous positive airway pressure (CPAP) for his sleep apnea, starting 1-year poststroke; and (2) repetitive transcranial magnetic brain stimulation (TMS), starting 2 years poststroke. BACKGROUND: Language data were acquired beyond the spontaneous recovery period of 3 to 6 months poststroke onset. CPAP restores adequate oxygen flow throughout all stages of sleep, and may improve cognition. A series of slow, 1 Hz repetitive TMS treatments to suppress a posterior portion of right pars triangularis has been shown to improve phrase length and naming in chronic nonfluent aphasia. METHOD: The Boston Diagnostic Aphasia Examination and Boston Naming Test were administered pre-CPAP, and after 2 to 5 months of CPAP. These same tests were administered pre-TMS, and at 3 and 6 months post-TMS, and again 2.4 years later. RESULTS: Post-CPAP testing showed increased Phrase Length, Auditory Comprehension, and naming Animals and Tools/Implements (Boston Diagnostic Aphasia Examination). Testing at 3 and 6 months post-TMS showed significant increase in Phrase Length, Auditory Comprehension, and Boston Naming Test compared with pre-TMS. These gains were retained at 2.4 years post-TMS. CPAP use continued throughout. CONCLUSIONS: Physiologic treatment interventions may promote language recovery in chronic aphasia.
Authors: Margaret A Naeser; Paula I Martin; Marjorie Nicholas; Errol H Baker; Heidi Seekins; Masahito Kobayashi; Hugo Theoret; Felipe Fregni; Jose Maria-Tormos; Jacquie Kurland; Karl W Doron; Alvaro Pascual-Leone Journal: Brain Lang Date: 2005-04 Impact factor: 2.381
Authors: Argye E Hillis; Jonathan T Kleinman; Melissa Newhart; Jennifer Heidler-Gary; Rebecca Gottesman; Peter B Barker; Eric Aldrich; Rafael Llinas; Robert Wityk; Priyanka Chaudhry Journal: J Neurosci Date: 2006-08-02 Impact factor: 6.167
Authors: Bruce Crosson; Anna Bacon Moore; Kaundinya Gopinath; Keith D White; Christina E Wierenga; Megan E Gaiefsky; Katherine S Fabrizio; Kyung K Peck; David Soltysik; Christina Milsted; Richard W Briggs; Tim W Conway; Leslie J Gonzalez Rothi Journal: J Cogn Neurosci Date: 2005-03 Impact factor: 3.225
Authors: Margaret A Naeser; Paula I Martin; Marjorie Nicholas; Errol H Baker; Heidi Seekins; Nancy Helm-Estabrooks; Carol Cayer-Meade; Masahito Kobayashi; Hugo Theoret; Felipe Fregni; Jose Maria Tormos; Jacquie Kurland; Karl W Doron; Alvaro Pascual-Leone Journal: Neurocase Date: 2005-06 Impact factor: 0.881
Authors: Lutz Winhuisen; Alexander Thiel; Birgit Schumacher; Josef Kessler; Jobst Rudolf; Walter F Haupt; Wolf D Heiss Journal: Stroke Date: 2005-07-14 Impact factor: 7.914
Authors: Margaret A Naeser; Paula I Martin; Ethan Treglia; Michael Ho; Elina Kaplan; Shahid Bashir; Roy Hamilton; H Branch Coslett; Alvaro Pascual-Leone Journal: Restor Neurol Neurosci Date: 2010 Impact factor: 2.406
Authors: Elina Kaplan; Margaret A Naeser; Paula I Martin; Michael Ho; Yunyan Wang; Errol Baker; Alvaro Pascual-Leone Journal: Neuroimage Date: 2010-05-08 Impact factor: 6.556
Authors: Margaret A Naeser; Paula I Martin; Michael Ho; Ethan Treglia; Elina Kaplan; Shahid Bashir; Alvaro Pascual-Leone Journal: Arch Phys Med Rehabil Date: 2012-01 Impact factor: 3.966
Authors: Denise Y Harvey; Jamie Podell; Peter E Turkeltaub; Olufunsho Faseyitan; H Branch Coslett; Roy H Hamilton Journal: Cogn Behav Neurol Date: 2017-12 Impact factor: 1.600
Authors: Paula I Martin; Ethan Treglia; Margaret A Naeser; Michael D Ho; Errol H Baker; Elizabeth G Martin; Shahid Bashir; Alvaro Pascual-Leone Journal: Restor Neurol Neurosci Date: 2014 Impact factor: 2.406