Paula I Martin1, Ethan Treglia1, Margaret A Naeser1, Michael D Ho1, Errol H Baker1, Elizabeth G Martin1, Shahid Bashir2, Alvaro Pascual-Leone3. 1. Veterans Affairs Boston Healthcare System and the Harold Goodglass Boston University Aphasia Research Center, Department of Neurology, Boston University School of Medicine, Boston, MA, USA. 2. Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. 3. Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA Institut Universitari de Neurorehabilitació Guttmann-UAB, Badalona, Spain.
Abstract
PURPOSE: The purpose of this study was to investigate: 1) the feasibilty of administering a modified CILT (mCILT) treatment session immediately after TMS; and 2) if this combined therapy could improve naming and elicited propositional speech in chronic, nonfluent aphasia. METHODS: Two chronic stroke patients with nonfluent aphasia (mild-moderate and severe) each received twenty minutes of rTMS to suppress the right pars triangularis, followed immediately by three hours of mCILT (5 days/week, 2 weeks). (Each patient had received TMS alone, 2-6 years prior.) Language evaluations were performed pre- TMS+mCILT, and post- at 1-2 months, and 6 or 16 months. RESULTS: Both patients showed significant improvements in naming pictures, and elicited propositional speech at 1-2 months post- TMS+mCILT. The improved naming was still present at 6 months post- TMS+mCILT for P2; but not at 16 months post- TMS+mCILT for P1. CONCLUSIONS: It is feasible to administer mCILT for three hours immediately after a TMS session. It is unknown if the significant improvements in naming pictures, and elicited propositional speech were associated with the second series of TMS, or this first series of mCILT, or a combination of both. A larger, sham controlled clinical trial is warranted.
PURPOSE: The purpose of this study was to investigate: 1) the feasibilty of administering a modified CILT (mCILT) treatment session immediately after TMS; and 2) if this combined therapy could improve naming and elicited propositional speech in chronic, nonfluent aphasia. METHODS: Two chronic strokepatients with nonfluent aphasia (mild-moderate and severe) each received twenty minutes of rTMS to suppress the right pars triangularis, followed immediately by three hours of mCILT (5 days/week, 2 weeks). (Each patient had received TMS alone, 2-6 years prior.) Language evaluations were performed pre- TMS+mCILT, and post- at 1-2 months, and 6 or 16 months. RESULTS: Both patients showed significant improvements in naming pictures, and elicited propositional speech at 1-2 months post- TMS+mCILT. The improved naming was still present at 6 months post- TMS+mCILT for P2; but not at 16 months post- TMS+mCILT for P1. CONCLUSIONS: It is feasible to administer mCILT for three hours immediately after a TMS session. It is unknown if the significant improvements in naming pictures, and elicited propositional speech were associated with the second series of TMS, or this first series of mCILT, or a combination of both. A larger, sham controlled clinical trial is warranted.
Entities:
Keywords:
TMS; aphasia; constraint-induced language therapy; speech therapy; stroke rehabilitation
Authors: Margaret A Naeser; Paula I Martin; Ethan Treglia; Michael Ho; Elina Kaplan; Shahid Bashir; Roy Hamilton; H Branch Coslett; Alvaro Pascual-Leone Journal: Restor Neurol Neurosci Date: 2010 Impact factor: 2.406
Authors: Margaret A Naeser; Paula I Martin; Marjorie Nicholas; Errol H Baker; Heidi Seekins; Masahito Kobayashi; Hugo Theoret; Felipe Fregni; Jose Maria-Tormos; Jacquie Kurland; Karl W Doron; Alvaro Pascual-Leone Journal: Brain Lang Date: 2005-04 Impact factor: 2.381
Authors: C H S Barwood; B E Murdoch; B-M Whelan; D Lloyd; S Riek; J D O' Sullivan; A Coulthard; A Wong Journal: Eur J Neurol Date: 2010-12-07 Impact factor: 6.089
Authors: Roy H Hamilton; Linda Sanders; Jennifer Benson; Olufunsho Faseyitan; Catherine Norise; Margaret Naeser; Paula Martin; H Branch Coslett Journal: Brain Lang Date: 2010-02-16 Impact factor: 2.381
Authors: Paula I Martin; Margaret A Naeser; Michael Ho; Ethan Treglia; Elina Kaplan; Errol H Baker; Alvaro Pascual-Leone Journal: Curr Neurol Neurosci Rep Date: 2009-11 Impact factor: 5.081