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Literature DB >> 20297809

The solution structure of (+)-spongistatin 1 in DMSO.

Onur Atasoylu¹, George Furst, Christina Risatti, Amos B Smith.

Abstract

The solution structure of (+)-spongistatin 1 (1) has been determined via 1- and 2-D NMR techniques in conjunction with extensive in silico conformational analysis to comprise a mixture of 4 major rapidly interconverting conformational families.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2010 PMID： 20297809 PMCID： PMC2856070 DOI： 10.1021/ol100417d

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

6 in total

1. Janocchio--a Java applet for viewing 3D structures and calculating NMR couplings and NOEs.

Authors: David A Evans; Michael J Bodkin; S Richard Baker; Gary J Sharman
Journal: Magn Reson Chem Date: 2007-07 Impact factor: 2.447

2. Improved spectral resolution in cosy 1H NMR spectra of proteins via double quantum filtering.

Authors: M Rance; O W Sørensen; G Bodenhausen; G Wagner; R R Ernst; K Wüthrich
Journal: Biochem Biophys Res Commun Date: 1983-12-16 Impact factor: 3.575

3. Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin.

Authors: R Bai; Z A Cichacz; C L Herald; G R Pettit; E Hamel
Journal: Mol Pharmacol Date: 1993-10 Impact factor: 4.436

4. Altohyrtins B and C and 5-desacetylaltohyrtin A, potent cytotoxic macrolide congeners of altohyrtin A, from the Okinawan marine sponge Hyrtios altum.

Authors: M Kobayashi; S Aoki; H Sakai; N Kihara; T Sasaki; I Kitagawa
Journal: Chem Pharm Bull (Tokyo) Date: 1993-05 Impact factor: 1.645

5. The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain.

Authors: R Bai; G F Taylor; Z A Cichacz; C L Herald; J A Kepler; G R Pettit; E Hamel
Journal: Biochemistry Date: 1995-08-01 Impact factor: 3.162

The solution structure of (+)-spongistatin 1 in DMSO.

1. Janocchio--a Java applet for viewing 3D structures and calculating NMR couplings and NOEs.

2. Improved spectral resolution in cosy 1H NMR spectra of proteins via double quantum filtering.

3. Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin.

4. Altohyrtins B and C and 5-desacetylaltohyrtin A, potent cytotoxic macrolide congeners of altohyrtin A, from the Okinawan marine sponge Hyrtios altum.

5. The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain.

6. Compensation of refocusing inefficiency with synchronized inversion sweep (CRISIS) in multiplicity-edited HSQC.

Review 1. Conformation-activity relationships of polyketide natural products.

2. In vitro and in vivo anticancer activity of (+)-spongistatin 1.

3. Conformational preferences of zampanolide and dactylolide.

4. Rhodium(i) complexes derived from tris(isopropyl)-azaphosphatrane-controlling the metal-ligand interplay.

5. Hydrocarbon Macrocycle Conformer Ensembles and ¹³ C-NMR Spectra.

Review 6. Reconciling Simulations and Experiments With BICePs: A Review.