| Literature DB >> 2027128 |
D K Dedrick1, R Goulet, L Huston, S A Goldstein, G G Bole.
Abstract
Alterations in trabecular subchondral bone have been measured using a microscopic computed tomography scanner in the guinea pig hind-limb myectomy model of osteoarthritis. These bone changes can be found as early as histologic changes in cartilage. To evaluate the influence of the myectomy on the animals, a gait study was performed. This data reveals an alteration in acceleration at the foot-flat phase of gait in the operated limb only, providing early quantification of the interaction between mechanics and biology.Entities:
Mesh:
Year: 1991 PMID: 2027128
Source DB: PubMed Journal: J Rheumatol Suppl ISSN: 0380-0903