Literature DB >> 2026210

Participation of interneurons in penicillin-induced epileptic discharges.

R Domann1, S Uhlig, T Dorn, O W Witte.   

Abstract

Interneurons of rat motor cortex in vivo and of rat hippocampal slices were studied during penicillin-induced epileptic discharges. Synchronous with pyramidal cells, they showed transient depolarizations similar to paroxysmal depolarization shifts in pyramidal cells. The transient depolarizations were followed by hyperpolarizing or depolarizing afterpotentials lasting 600 to 1200 ms. During the transient depolarizations and the afterdepolarizations the interneurons discharged with increased frequency. This may contribute to the enlarged and prolonged synaptic inhibitions following interictal discharges in pyramidal cells.

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Year:  1991        PMID： 2026210     DOI： 10.1007/bf00229848

Source DB:  PubMed          Journal:  Exp Brain Res        ISSN： 0014-4819            Impact factor:   1.972


  16 in total

1.  CORTICAL CELLULAR PHENOMENA IN EXPERIMENTAL EPILEPSY: INTERICTAL MANIFESTATIONS.

Authors:  H MATSUMOTO; C A MARSAN
Journal:  Exp Neurol       Date:  1964-04       Impact factor: 5.330

2.  Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex.

Authors:  D A McCormick; B W Connors; J W Lighthall; D A Prince
Journal:  J Neurophysiol       Date:  1985-10       Impact factor: 2.714

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Authors:  D R Curtis; A W Duggan; D Felix; G A Johnston
Journal:  Nature       Date:  1970-06-27       Impact factor: 49.962

4.  Inhibition in "epileptic" neurons.

Authors:  D A Prince
Journal:  Exp Neurol       Date:  1968-07       Impact factor: 5.330

5.  Physiological and morphological identification of a nonpyramidal hippocampal cell type.

Authors:  P A Schwartzkroin; L H Mathers
Journal:  Brain Res       Date:  1978-11-17       Impact factor: 3.252

Review 6.  Cellular mechanisms of epilepsy: a status report.

Authors:  M A Dichter; G F Ayala
Journal:  Science       Date:  1987-07-10       Impact factor: 47.728

7.  Calcium-dependent potassium current following penicillin-induced epileptiform discharges in the hippocampal slice.

Authors:  R Domann; T Dorn; O W Witte
Journal:  Exp Brain Res       Date:  1989       Impact factor: 1.972

8.  Local circuit interactions between oriens/alveus interneurons and CA1 pyramidal cells in hippocampal slices: electrophysiology and morphology.

Authors:  J C Lacaille; A L Mueller; D D Kunkel; P A Schwartzkroin
Journal:  J Neurosci       Date:  1987-07       Impact factor: 6.167

Review 9.  Extracellular calcium and potassium concentration changes in chronic epileptic brain tissue.

Authors:  U Heinemann; A Konnerth; R Pumain; W J Wadman
Journal:  Adv Neurol       Date:  1986

10.  Relative contributions of passive equilibrium and active transport to the distribution of chloride in mammalian cortical neurons.

Authors:  S M Thompson; R A Deisz; D A Prince
Journal:  J Neurophysiol       Date:  1988-07       Impact factor: 2.714
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  6 in total

1.  Ictal epileptiform activity is facilitated by hippocampal GABAA receptor-mediated oscillations.

Authors:  R Köhling; M Vreugdenhil; E Bracci; J G Jefferys
Journal:  J Neurosci       Date:  2000-09-15       Impact factor: 6.167

2.  Simulation of gamma rhythms in networks of interneurons and pyramidal cells.

Authors:  R D Traub; J G Jefferys; M A Whittington
Journal:  J Comput Neurosci       Date:  1997-04       Impact factor: 1.621

3.  Seizure-like activity in the disinhibited CA1 minislice of adult guinea-pigs.

Authors:  S Karnup; A Stelzer
Journal:  J Physiol       Date:  2001-05-01       Impact factor: 5.182

4.  Analysis of the propagation of disinhibition-induced after-discharges along the guinea-pig hippocampal slice in vitro.

Authors:  R D Traub; J G Jefferys; R Miles
Journal:  J Physiol       Date:  1993-12       Impact factor: 5.182

5.  Enhanced NMDA conductance can account for epileptiform activity induced by low Mg2+ in the rat hippocampal slice.

Authors:  R D Traub; J G Jefferys; M A Whittington
Journal:  J Physiol       Date:  1994-08-01       Impact factor: 5.182

6.  Inhibitory mechanisms in epileptiform activity induced by low magnesium.

Authors:  C H Westerhoff; R Domann; O W Witte
Journal:  Pflugers Arch       Date:  1995-06       Impact factor: 3.657
  6 in total

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