Literature DB >> 2024502

An internal domain of the hepatitis B virus X antigen is necessary for transactivating activity.

S E Ritter1, T M Whitten, A T Quets, R H Schloemer.   

Abstract

A number of deletion mutants of the hepatitis B viral X antigen had been constructed and assayed for their ability to transactivate heterologous viral regulatory elements. Neither the N-terminal nor the C-terminal amino acid residues were required for transactivating activity. Transactivating activity that resided within amino acid residues 32 to 148 of the X antigen did not show any target DNA sequence or cell line specificity.

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Year:  1991        PMID: 2024502     DOI: 10.1016/0042-6822(91)90626-m

Source DB:  PubMed          Journal:  Virology        ISSN: 0042-6822            Impact factor:   3.616


  6 in total

1.  XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation.

Authors:  N Kuzhandaivelu; Y S Cong; C Inouye; W M Yang; E Seto
Journal:  Nucleic Acids Res       Date:  1996-12-01       Impact factor: 16.971

2.  Disruption of the function of tumor-suppressor gene p53 by the hepatitis B virus X protein and hepatocarcinogenesis.

Authors:  S Takada; N Tsuchida; M Kobayashi; K Koike
Journal:  J Cancer Res Clin Oncol       Date:  1995       Impact factor: 4.553

Review 3.  Hepatitis B virus and hepatocellular carcinoma.

Authors:  P Arbuthnot; M Kew
Journal:  Int J Exp Pathol       Date:  2001-04       Impact factor: 1.925

4.  A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function.

Authors:  V Kumar; N Jayasuryan; R Kumar
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-28       Impact factor: 11.205

5.  Regulation of transforming growth factor-beta 1 expression by the hepatitis B virus (HBV) X transactivator. Role in HBV pathogenesis.

Authors:  Y D Yoo; H Ueda; K Park; K C Flanders; Y I Lee; G Jay; S J Kim
Journal:  J Clin Invest       Date:  1996-01-15       Impact factor: 14.808

6.  The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks.

Authors:  H S Chen; S Kaneko; R Girones; R W Anderson; W E Hornbuckle; B C Tennant; P J Cote; J L Gerin; R H Purcell; R H Miller
Journal:  J Virol       Date:  1993-03       Impact factor: 5.103

  6 in total

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