Literature DB >> 20233925

Prokaryotic ubiquitin-like protein provides a two-part degron to Mycobacterium proteasome substrates.

Kristin E Burns1, Michael J Pearce, K Heran Darwin.   

Abstract

Prokaryotic ubiquitin-like protein (Pup) is a posttranslational modifier that targets proteins for degradation by the mycobacterial proteasome. We show that the disordered amino terminus of Pup is required for degradation, while the helical carboxyl terminus mediates its attachment to proteins. Thus, Pup has distinct regions that either interact with pupylation enzymes or initiate proteasomal degradation.

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Year:  2010        PMID： 20233925      PMCID： PMC2876485          DOI： 10.1128/JB.01639-09

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  20 in total

1.  A distinct structural region of the prokaryotic ubiquitin-like protein (Pup) is recognized by the N-terminal domain of the proteasomal ATPase Mpa.

Authors:  Markus Sutter; Frank Striebel; Fred F Damberger; Frédéric H-T Allain; Eilika Weber-Ban
Journal:  FEBS Lett       Date:  2009-09-15       Impact factor: 4.124

2.  Crystal structure of inositol 1-phosphate synthase from Mycobacterium tuberculosis, a key enzyme in phosphatidylinositol synthesis.

Authors:  Richard A Norman; Mark S B McAlister; Judith Murray-Rust; Farahnaz Movahedzadeh; Neil G Stoker; Neil Q McDonald
Journal:  Structure       Date:  2002-03       Impact factor: 5.006

3.  Prokaryotic ubiquitin-like protein pup is intrinsically disordered.

Authors:  Xiang Chen; William C Solomon; Yang Kang; Francisca Cerda-Maira; K Heran Darwin; Kylie J Walters
Journal:  J Mol Biol       Date:  2009-07-14       Impact factor: 5.469

4.  The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide.

Authors:  K Heran Darwin; Sabine Ehrt; José-Carlos Gutierrez-Ramos; Nadine Weich; Carl F Nathan
Journal:  Science       Date:  2003-12-12       Impact factor: 47.728

Review 5.  Targeting proteins for degradation.

Authors:  Erin K Schrader; Kristine G Harstad; Andreas Matouschek
Journal:  Nat Chem Biol       Date:  2009-11       Impact factor: 15.040

Review 6.  Origin and function of ubiquitin-like proteins.

Authors:  Mark Hochstrasser
Journal:  Nature       Date:  2009-03-26       Impact factor: 49.962

Review 7.  Prokaryotic ubiquitin-like protein (Pup), proteasomes and pathogenesis.

Authors:  K Heran Darwin
Journal:  Nat Rev Microbiol       Date:  2009-06-01       Impact factor: 60.633

Review 8.  The Mycobacterium tuberculosis proteasome: more than just a barrel-shaped protease.

Authors:  Francisca Cerda-Maira; K Heran Darwin
Journal:  Microbes Infect       Date:  2009-08-09       Impact factor: 2.700

9.  Pup, a prokaryotic ubiquitin-like protein, is an intrinsically disordered protein.

Authors:  Shanhui Liao; Qiang Shang; Xuecheng Zhang; Jiahai Zhang; Chao Xu; Xiaoming Tu
Journal:  Biochem J       Date:  2009-08-13       Impact factor: 3.857

10.  Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] .

Authors:  Richard A Festa; Fiona McAllister; Michael J Pearce; Julian Mintseris; Kristin E Burns; Steven P Gygi; K Heran Darwin
Journal:  PLoS One       Date:  2010-01-06       Impact factor: 3.240
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  35 in total

Review 1.  Bacterial Proteasomes: Mechanistic and Functional Insights.

Authors:  Samuel H Becker; K Heran Darwin
Journal:  Microbiol Mol Biol Rev       Date:  2016-12-14       Impact factor: 11.056

2.  Reconstitution of the Mycobacterium tuberculosis pupylation pathway in Escherichia coli.

Authors:  Francisca A Cerda-Maira; Fiona McAllister; Nadine J Bode; Kristin E Burns; Steven P Gygi; K Heran Darwin
Journal:  EMBO Rep       Date:  2011-07-08       Impact factor: 8.807

Review 3.  Bacterial Proteasomes.

Authors:  Jordan B Jastrab; K Heran Darwin
Journal:  Annu Rev Microbiol       Date:  2015       Impact factor: 15.500

4.  Survival of mycobacteria depends on proteasome-mediated amino acid recycling under nutrient limitation.

Authors:  Yifat Elharar; Ziv Roth; Inna Hermelin; Alexandra Moon; Gabriella Peretz; Yael Shenkerman; Marina Vishkautzan; Isam Khalaila; Eyal Gur
Journal:  EMBO J       Date:  2014-07-01       Impact factor: 11.598

5.  Structural Basis for the Species-Selective Binding of N,C-Capped Dipeptides to the Mycobacterium tuberculosis Proteasome.

Authors:  Hao-Chi Hsu; Pradeep K Singh; Hao Fan; Rong Wang; George Sukenick; Carl Nathan; Gang Lin; Huilin Li
Journal:  Biochemistry       Date:  2016-12-27       Impact factor: 3.162

Review 6.  In-Cell NMR Spectroscopy of Intrinsically Disordered Proteins.

Authors:  Nicholas Sciolino; David S Burz; Alexander Shekhtman
Journal:  Proteomics       Date:  2019-01-15       Impact factor: 3.984

7.  Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrates for degradation.

Authors:  Tao Wang; K Heran Darwin; Huilin Li
Journal:  Nat Struct Mol Biol       Date:  2010-10-17       Impact factor: 15.369

Review 8.  Prokaryotic ubiquitin-like protein modification.

Authors:  Julie A Maupin-Furlow
Journal:  Annu Rev Microbiol       Date:  2014-05-29       Impact factor: 15.500

Review 9.  The pup-proteasome system of Mycobacterium tuberculosis.

Authors:  Marie I Samanovic; Huilin Li; K Heran Darwin
Journal:  Subcell Biochem       Date:  2013

10.  Allosteric transitions direct protein tagging by PafA, the prokaryotic ubiquitin-like protein (Pup) ligase.

Authors:  Naomi Ofer; Nadav Forer; Maayan Korman; Marina Vishkautzan; Isam Khalaila; Eyal Gur
Journal:  J Biol Chem       Date:  2013-03-07       Impact factor: 5.157
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