Literature DB >> 20233660

New 3-methylquinoxaline-2-carboxamide 1,4-di-N-oxide derivatives as anti-Mycobacterium tuberculosis agents.

Saioa Ancizu1, Elsa Moreno, Beatriz Solano, Raquel Villar, Asunción Burguete, Enrique Torres, Silvia Pérez-Silanes, Ignacio Aldana, Antonio Monge.   

Abstract

Mycobacterium tuberculosis (M.Tb) is a bacillus capable of causing a chronic and fatal condition in humans known as tuberculosis (TB). It is estimated that there are 8 million new cases of TB per year and 3.1 million infected people die annually. Thirty-six new amide quinoxaline 1,4-di-N-oxide derivatives have been synthesized and evaluated as potential anti-tubercular agents, obtaining biological values similar to the reference compound, Rifampin (RIF). Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20233660     DOI： 10.1016/j.bmc.2010.02.024

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  8 in total

1.  E-2-[3-(3,4-dichlorophenyl)-1-oxo-2-propenyl]-3-methylquinoxaline-1,4-dioxide: a lead antitubercular agent which alters mitochondrial respiration in rat liver.

Authors:  Umashankar Das; Swagatika Das; Brian Bandy; Dennis K J Gorecki; Jonathan R Dimmock
Journal:  Eur J Med Chem       Date:  2010-07-24       Impact factor: 6.514

2.  Discovery and optimization of benzotriazine di-N-oxides targeting replicating and nonreplicating Mycobacterium tuberculosis.

Authors:  Sidharth Chopra; Gary A Koolpe; Arlyn A Tambo-Ong; Karen N Matsuyama; Kenneth J Ryan; Tran B Tran; Rupa S Doppalapudi; Edward S Riccio; Lalitha V Iyer; Carol E Green; Baojie Wan; Scott G Franzblau; Peter B Madrid
Journal:  J Med Chem       Date:  2012-06-25       Impact factor: 7.446

3.  Design and synthesis of novel quinoxaline derivatives as potential candidates for treatment of multidrug-resistant and latent tuberculosis.

Authors:  Mery Santivañez-Veliz; Silvia Pérez-Silanes; Enrique Torres; Elsa Moreno-Viguri
Journal:  Bioorg Med Chem Lett       Date:  2016-03-18       Impact factor: 2.823

4.  Studies on log Po/w of quinoxaline di-N-oxides: a comparison of RP-HPLC experimental and predictive approaches.

Authors:  Elsa Moreno; Elisabetta Gabano; Enrique Torres; James A Platts; Mauro Ravera; Ignacio Aldana; Antonio Monge; Silvia Pérez-Silanes
Journal:  Molecules       Date:  2011-09-13       Impact factor: 4.411

5.  New quinoxaline derivatives as potential MT₁ and MT₂ receptor ligands.

Authors:  Saioa Ancizu; Nerea Castrillo; Silvia Pérez-Silanes; Ignacio Aldana; Antonio Monge; Philippe Delagrange; Daniel-Henry Caignard; Silvia Galiano
Journal:  Molecules       Date:  2012-06-25       Impact factor: 4.411

6.  Design, synthesis, and molecular docking studies of diphenylquinoxaline-6-carbohydrazide hybrids as potent α-glucosidase inhibitors.

Authors:  Keyvan Pedrood; Zahra Rezaei; Kimia Khavaninzadeh; Bagher Larijani; Aida Iraji; Samanesadat Hosseini; Somayeh Mojtabavi; Mehdi Dianatpour; Hossein Rastegar; Mohammad Ali Faramarzi; Haleh Hamedifar; Mir Hamed Hajimiri; Mohammad Mahdavi
Journal:  BMC Chem       Date:  2022-07-31

7.  Chemotherapeutic interventions against tuberculosis.

Authors:  Neeraj Shakya; Gaurav Garg; Babita Agrawal; Rakesh Kumar
Journal:  Pharmaceuticals (Basel)       Date:  2012-06-28

8.  Synthesis and Antimicrobial Activity of Some New Substituted Quinoxalines.

Authors:  Mohamed A El-Atawy; Ezzat A Hamed; Mahjoba Alhadi; Alaa Z Omar
Journal:  Molecules       Date:  2019-11-19       Impact factor: 4.411
  8 in total

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