Literature DB >> 20228798

Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).

Andre Franke1, Tobias Balschun, Christian Sina, David Ellinghaus, Robert Häsler, Gabriele Mayr, Mario Albrecht, Michael Wittig, Eva Buchert, Susanna Nikolaus, Christian Gieger, H Erich Wichmann, Jurgita Sventoraityte, Limas Kupcinskas, Clive M Onnie, Maria Gazouli, Nicholas P Anagnou, David Strachan, Wendy L McArdle, Christopher G Mathew, Paul Rutgeerts, Séverine Vermeire, Morten H Vatn, Michael Krawczak, Philip Rosenstiel, Tom H Karlsen, Stefan Schreiber.   

Abstract

We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P(rs7809799) = 8.81 x 10(-11) and P(rs5771069) = 4.21 x 10(-8), respectively).

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Year:  2010        PMID： 20228798     DOI： 10.1038/ng.553

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  15 in total

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Journal:  Nat Genet       Date:  2008-06-29       Impact factor: 38.330

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Review 5.  Structure and signalling in the IL-17 receptor family.

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7.  Confirmation of the novel association at the BTNL2 locus with ulcerative colitis.

Authors:  S Pathan; R E Gowdy; R Cooney; J B Beckly; L Hancock; C Guo; J C Barrett; A Morris; D P Jewell
Journal:  Tissue Antigens       Date:  2009-07-29

8.  Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility.

Authors:  Andre Franke; Tobias Balschun; Tom H Karlsen; Jurgita Sventoraityte; Susanna Nikolaus; Gabriele Mayr; Francisco S Domingues; Mario Albrecht; Michael Nothnagel; David Ellinghaus; Christian Sina; Clive M Onnie; Rinse K Weersma; Pieter C F Stokkers; Cisca Wijmenga; Maria Gazouli; David Strachan; Wendy L McArdle; Séverine Vermeire; Paul Rutgeerts; Philip Rosenstiel; Michael Krawczak; Morten H Vatn; Christopher G Mathew; Stefan Schreiber
Journal:  Nat Genet       Date:  2008-10-05       Impact factor: 38.330

9.  A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1.

Authors:  Jochen Hampe; Andre Franke; Philip Rosenstiel; Andreas Till; Markus Teuber; Klaus Huse; Mario Albrecht; Gabriele Mayr; Francisco M De La Vega; Jason Briggs; Simone Günther; Natalie J Prescott; Clive M Onnie; Robert Häsler; Bence Sipos; Ulrich R Fölsch; Thomas Lengauer; Matthias Platzer; Christopher G Mathew; Michael Krawczak; Stefan Schreiber
Journal:  Nat Genet       Date:  2006-12-31       Impact factor: 38.330

10.  IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells.

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Journal:  J Exp Med       Date:  2007-07-16       Impact factor: 14.307
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  85 in total

Review 1.  The impact of perinatal immune development on mucosal homeostasis and chronic inflammation.

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2.  Distinct and overlapping genetic loci in Crohn's disease and ulcerative colitis: correlations with pathogenesis.

Authors:  Matti Waterman; Wei Xu; Joanne M Stempak; Raquel Milgrom; Charles N Bernstein; Anne M Griffiths; Gordon R Greenberg; A Hillary Steinhart; Mark S Silverberg
Journal:  Inflamm Bowel Dis       Date:  2010-12-10       Impact factor: 5.325

3.  Whole-exome Sequence Analysis Implicates Rare Il17REL Variants in Familial and Sporadic Inflammatory Bowel Disease.

Authors:  Mark M Sasaki; Andrew D Skol; Eric A Hungate; Riyue Bao; Lei Huang; Stacy A Kahn; James M Allan; Steven R Brant; Dermot P B McGovern; Inga Peter; Mark S Silverberg; Judy H Cho; Barbara S Kirschner; Kenan Onel
Journal:  Inflamm Bowel Dis       Date:  2016-01       Impact factor: 5.325

4.  eQTL analysis links inflammatory bowel disease associated 1q21 locus to ECM1 gene.

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Review 5.  Autophagy and human diseases.

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Review 6.  Resolution of Crohn's disease.

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Journal:  Semin Immunopathol       Date:  2019-09-24       Impact factor: 9.623

7.  'Nodophagy': New crossroads in Crohn disease pathogenesis.

Authors:  Mahendrasingh Ramjeet; Séamus Hussey; Dana J Philpott; Leonardo H Travassos
Journal:  Gut Microbes       Date:  2010-08-08

Review 8.  IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases.

Authors:  Michele W L Teng; Edward P Bowman; Joshua J McElwee; Mark J Smyth; Jean-Laurent Casanova; Andrea M Cooper; Daniel J Cua
Journal:  Nat Med       Date:  2015-06-29       Impact factor: 53.440

9.  A cross-ethnic survey of CFB and SLC44A4, Indian ulcerative colitis GWAS hits, underscores their potential role in disease susceptibility.

Authors:  Aditi Gupta; Garima Juyal; Ajit Sood; Vandana Midha; Keiko Yamazaki; Arnau Vich Vila; Motohiro Esaki; Toshiyuki Matsui; Atsushi Takahashi; Michiaki Kubo; Rinse K Weersma; B K Thelma
Journal:  Eur J Hum Genet       Date:  2016-10-19       Impact factor: 4.246

10.  Fungal Dysbiosis in Mucosa-associated Microbiota of Crohn's Disease Patients.

Authors:  Giuseppina Liguori; Bruno Lamas; Mathias L Richard; Giovanni Brandi; Gregory da Costa; Thomas W Hoffmann; Massimo Pierluigi Di Simone; Carlo Calabrese; Gilberto Poggioli; Philippe Langella; Massimo Campieri; Harry Sokol
Journal:  J Crohns Colitis       Date:  2015-11-15       Impact factor: 9.071
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