OBJECTIVE: Evaluation of the efficacy of a patented, compound herbal preparation (CHP) in improving attention, cognition, and impulse control in children with ADHD. DESIGN: A randomized, double-blind, placebo-controlled trial. SETTING: University-affiliated tertiary medical center. PARTICIPANTS: 120 children newly diagnosed with ADHD, meeting DSM-IV criteria. INTERVENTION: Random assignment to the herbal treatment group (n = 80) or control group (placebo; n = 40); 73 patients in the treatment group (91%) and 19 in the control group (48%) completed the 4-month trial. OUTCOME MEASURE: Test of Variables of Attention (TOVA) administered before and after the treatment period; overall score and 4 subscales. RESULTS: The treatment group showed substantial, statistically significant improvement in the 4 subscales and overall TOVA scores, compared with no improvement in the control group, which persisted in an intention-to-treat analysis. CONCLUSIONS: The well-tolerated CHP demonstrated improved attention, cognition, and impulse control in the intervention group, indicating promise for ADHD treatment in children.
RCT Entities:
OBJECTIVE: Evaluation of the efficacy of a patented, compound herbal preparation (CHP) in improving attention, cognition, and impulse control in children with ADHD. DESIGN: A randomized, double-blind, placebo-controlled trial. SETTING: University-affiliated tertiary medical center. PARTICIPANTS: 120 children newly diagnosed with ADHD, meeting DSM-IV criteria. INTERVENTION: Random assignment to the herbal treatment group (n = 80) or control group (placebo; n = 40); 73 patients in the treatment group (91%) and 19 in the control group (48%) completed the 4-month trial. OUTCOME MEASURE: Test of Variables of Attention (TOVA) administered before and after the treatment period; overall score and 4 subscales. RESULTS: The treatment group showed substantial, statistically significant improvement in the 4 subscales and overall TOVA scores, compared with no improvement in the control group, which persisted in an intention-to-treat analysis. CONCLUSIONS: The well-tolerated CHP demonstrated improved attention, cognition, and impulse control in the intervention group, indicating promise for ADHD treatment in children.
Authors: Eric R Braverman; Catherine A Dennen; Mark S Gold; Abdalla Bowirrat; Ashim Gupta; David Baron; A Kenison Roy; David E Smith; Jean Lud Cadet; Kenneth Blum Journal: Int J Environ Res Public Health Date: 2022-04-30 Impact factor: 4.614
Authors: Jeanette M Johnstone; Andrew Hughes; Joshua Z Goldenberg; Amy R Romijn; Julia J Rucklidge Journal: Nutrients Date: 2020-11-04 Impact factor: 5.717