| Literature DB >> 20227875 |
Marianna Carbone1, Carlo Irace, Francesca Costagliola, Francesco Castelluccio, Guido Villani, Gonçalo Calado, Vinicius Padula, Guido Cimino, J Lucas Cervera, Rita Santamaria, Margherita Gavagnin.
Abstract
The chemical investigation of Azorean nudibranch mollusk Tambja ceutae led us to isolate a new member of the tambjamine family, tambjamine K (1). The bryozoan Bugula dentata, prey of the nudibranch, was also analyzed and found to contain compound 1 in very small amounts together with known blue pigment 2 and tambjamines A (3) and B (4). The structure of tambjamine 1 was elucidated by the interpretation of the spectroscopic data as well as by the comparison with related compounds. Compounds 1 and 2 possess antiproliferative activity, in particular, tambjamine K (1) displayed high cytotoxicity against both tumor and non-tumor mammalian cells. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20227875 DOI： 10.1016/j.bmcl.2010.02.020
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823