Literature DB >> 20227380

Development of a bioassay for detection of Wnt-binding affinities for individual frizzled receptors.

Kendra S Carmon1, David S Loose.   

Abstract

Wnts are secreted lipid-modified glycoproteins that carry out various signaling functions during development and in adult tissue. Wnt signaling is mediated by frizzled receptors (Fzds) at the cell surface and can be modulated by the secreted frizzled-related proteins (SFRPs) and other molecular antagonists. Abnormal Wnt signaling has been implicated in several diseases. However, due to the complexity of the Wnt signal and the lack of knowledge pertaining to the binding properties of different Wnt ligands, no therapeutic agents that target this pathway exist. Using a novel enzyme-linked immunosorbent assay (ELISA)-based technique, we were able to determine the first measurements of binding affinity for specific Wnt interactions. This study shows that purified Wnt3a, Wnt7a, and Wnt5a have different binding specificities for Fzds and SFRPs. Copyright (c) 2010 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20227380      PMCID： PMC2881539          DOI： 10.1016/j.ab.2010.03.009

Source DB:  PubMed          Journal:  Anal Biochem        ISSN： 0003-2697            Impact factor:   3.365


  16 in total

Review 1.  Wnt signaling and cancer.

Authors:  P Polakis
Journal:  Genes Dev       Date:  2000-08-01       Impact factor: 11.361

Review 2.  Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation?

Authors:  Marek Mlodzik
Journal:  Trends Genet       Date:  2002-11       Impact factor: 11.639

3.  Ligand receptor interactions in the Wnt signaling pathway in Drosophila.

Authors:  Chi-hwa Wu; Roel Nusse
Journal:  J Biol Chem       Date:  2002-08-29       Impact factor: 5.157

Review 4.  The Wnt signaling pathway in development and disease.

Authors:  Catriona Y Logan; Roel Nusse
Journal:  Annu Rev Cell Dev Biol       Date:  2004       Impact factor: 13.827

5.  Wnt proteins are lipid-modified and can act as stem cell growth factors.

Authors:  Karl Willert; Jeffrey D Brown; Esther Danenberg; Andrew W Duncan; Irving L Weissman; Tannishtha Reya; John R Yates; Roel Nusse
Journal:  Nature       Date:  2003-04-27       Impact factor: 49.962

6.  The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway.

Authors:  Isao Oishi; Hiroaki Suzuki; Nobuyuki Onishi; Ritsuko Takada; Shuichi Kani; Bisei Ohkawara; Ikue Koshida; Kentaro Suzuki; General Yamada; Georg C Schwabe; Stefan Mundlos; Hiroshi Shibuya; Shinji Takada; Yasuhiro Minami
Journal:  Genes Cells       Date:  2003-07       Impact factor: 1.891

7.  Secreted frizzled-related protein 4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial cancer cells.

Authors:  Kendra S Carmon; David S Loose
Journal:  Mol Cancer Res       Date:  2008-06       Impact factor: 5.852

Review 8.  Secreted antagonists of the Wnt signalling pathway.

Authors:  Yoshiaki Kawano; Robert Kypta
Journal:  J Cell Sci       Date:  2003-07-01       Impact factor: 5.285

9.  Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless.

Authors:  B J Wainwright; P J Scambler; P Stanier; E K Watson; G Bell; C Wicking; X Estivill; M Courtney; A Boue; P S Pedersen
Journal:  EMBO J       Date:  1988-06       Impact factor: 11.598

Review 10.  The Wnts.

Authors:  Jeffrey R Miller
Journal:  Genome Biol       Date:  2001-12-28       Impact factor: 13.583
View more
  20 in total

1.  LGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signaling.

Authors:  Kendra S Carmon; Qiushi Lin; Xing Gong; Anthony Thomas; Qingyun Liu
Journal:  Mol Cell Biol       Date:  2012-04-02       Impact factor: 4.272

Review 2.  The role of Ryk and Ror receptor tyrosine kinases in Wnt signal transduction.

Authors:  Jennifer Green; Roel Nusse; Renée van Amerongen
Journal:  Cold Spring Harb Perspect Biol       Date:  2014-02-01       Impact factor: 10.005

3.  Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy.

Authors:  Alisha Holtzhausen; Fei Zhao; Kathy S Evans; Masahito Tsutsui; Ciriana Orabona; Douglas S Tyler; Brent A Hanks
Journal:  Cancer Immunol Res       Date:  2015-06-03       Impact factor: 11.151

4.  Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs.

Authors:  Jacomijn P Dijksterhuis; Bolormaa Baljinnyam; Karen Stanger; Hakki O Sercan; Yun Ji; Osler Andres; Jeffrey S Rubin; Rami N Hannoush; Gunnar Schulte
Journal:  J Biol Chem       Date:  2015-01-20       Impact factor: 5.157

5.  Structure-based prediction of Wnt binding affinities for Frizzled-type cysteine-rich domains.

Authors:  Mark Agostino; Sebastian Öther-Gee Pohl; Arun Dharmarajan
Journal:  J Biol Chem       Date:  2017-05-22       Impact factor: 5.157

6.  Partial maintenance and long-term expansion of murine skin epithelial stem cells by Wnt-3a in vitro.

Authors:  Yukiteru Ouji; Shigeaki Ishizaka; Fukumi Nakamura-Uchiyama; Daisuke Okuzaki; Masahide Yoshikawa
Journal:  J Invest Dermatol       Date:  2014-12-01       Impact factor: 8.551

Review 7.  Wnt signaling and the control of human stem cell fate.

Authors:  J K Van Camp; S Beckers; D Zegers; W Van Hul
Journal:  Stem Cell Rev Rep       Date:  2014-04       Impact factor: 5.739

8.  Frizzled10 mediates WNT1 and WNT3A signaling in the dorsal spinal cord of the developing chick embryo.

Authors:  Ann Easton; Lydia Li; Ouma Onguka; Joseph S Ramahi; Rowena Suriben; Linda A Szabo; Camilla Teng; Baouyen Tran; Lisa M Galli; Roeben N Munji; Susan C Chapman; Rami N Hannoush; Laura W Burrus
Journal:  Dev Dyn       Date:  2014-04-01       Impact factor: 3.780

Review 9.  WNT Signaling in Cardiac and Vascular Disease.

Authors:  Sébastien Foulquier; Evangelos P Daskalopoulos; Gentian Lluri; Kevin C M Hermans; Arjun Deb; W Matthijs Blankesteijn
Journal:  Pharmacol Rev       Date:  2018-01       Impact factor: 25.468

Review 10.  WNT/Frizzled signalling: receptor-ligand selectivity with focus on FZD-G protein signalling and its physiological relevance: IUPHAR Review 3.

Authors:  J P Dijksterhuis; J Petersen; G Schulte
Journal:  Br J Pharmacol       Date:  2014-03       Impact factor: 8.739
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.