Literature DB >> 20222765

Urease inhibitors from Hypericum oblongifolium WALL.

Mohammad Arfan1, Mumtaz Ali, Habib Ahmad, Itrat Anis, Ajmal Khan, M Iqbal Choudhary, Muhammad Raza Shah.   

Abstract

The bioassay-guided fractionation of H. oblongifolium has led to the isolation of potent urease inhibitors 1-3. The structures were elucidated by NMR and mass spectroscopic techniques. Compound 2 showed a potent enzyme inhibition activity (IC(50) 20.96 +/- 0.93), which is comparatively higher than that for the standard thiourea (IC(50) 21.01 +/- 0.51 microM). Compounds 1 and 3 also showed a significant activity, with IC(50) 37.95 +/- 1.93 and 138.43 +/- 1.23 microM, respectively. The sub crude fractions (F1, F2, F3, and F4) were tested in vitro for their urease inhibition activity. Fractions F2 and F4 showed significant activity with IC(50) 140.37 +/- 1.93 and 167.43 +/- 3.03 microM, respectively.

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Year:  2010        PMID： 20222765     DOI： 10.3109/14756360903179385

Source DB:  PubMed          Journal:  J Enzyme Inhib Med Chem        ISSN： 1475-6366            Impact factor:   5.051


  10 in total

1.  5,7-Dihy-droxy-3,6-dimeth-oxy-2-(4-meth-oxy-phen-yl)-4H-chromen-4-one monohydrate.

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Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-10-02

2.  tert-Butyl 2-(4-nitro-phen-oxy)acetate.

Authors:  Qamar Ali; Itrat Anis; M Raza Shah; Seik Weng Ng
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-01-29

3.  7-[2-(3-Fur-yl)eth-yl]-7,8-dimethyl-3,5,6,6a,7,8,9,10-octa-hydro-1H-naphtho-[1,8a-c]furan-3-one.

Authors:  Akhtar Mohammad; Muhammad Raza Shah; Itrat Anis; Vickie McKee; Josef W A Frese
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-09-11

4.  Anti-Helicobacter pylori and urease inhibition activities of some traditional medicinal plants.

Authors:  Muhammad Amin; Farooq Anwar; Fauqia Naz; Tahir Mehmood; Nazamid Saari
Journal:  Molecules       Date:  2013-02-07       Impact factor: 4.411

5.  Sulfonamide-Linked Ciprofloxacin, Sulfadiazine and Amantadine Derivatives as a Novel Class of Inhibitors of Jack Bean Urease; Synthesis, Kinetic Mechanism and Molecular Docking.

Authors:  Pervaiz Ali Channar; Aamer Saeed; Fernando Albericio; Fayaz Ali Larik; Qamar Abbas; Mubashir Hassan; Hussain Raza; Sung-Yum Seo
Journal:  Molecules       Date:  2017-08-16       Impact factor: 4.411

6.  Green Synthesis, Characterization, Enzyme Inhibition, Antimicrobial Potential, and Cytotoxic Activity of Plant Mediated Silver Nanoparticle Using Ricinus communis Leaf and Root Extracts.

Authors:  Anadil Gul; Asmat Shaheen; Ijaz Ahmad; Baharullah Khattak; Munir Ahmad; Riaz Ullah; Ahmed Bari; Syed Saeed Ali; Abdulrahman Alobaid; Majid M Asmari; Hafiz M Mahmood
Journal:  Biomolecules       Date:  2021-02-02

7.  Expression, Purification, and Comparative Inhibition of Helicobacter pylori Urease by Regio-Selectively Alkylated Benzimidazole 2-Thione Derivatives.

Authors:  Salih Osman Mohammed; Sayed H El El Ashry; Asaad Khalid; Mohamed R Amer; Ahmed M Metwaly; Ibrahim H Eissa; Eslam B Elkaeed; Ahmed Elshobaky; Elsayed E Hafez
Journal:  Molecules       Date:  2022-01-27       Impact factor: 4.411

8.  Folecitin Isolated from Hypericum oblongifolium Exerts Neuroprotection against Lipopolysaccharide-Induced Neuronal Synapse and Memory Dysfunction via p-AKT/Nrf-2/HO-1 Signalling Pathway.

Authors:  Umar Farooq; Muhammad Umar Khayam Sahibzada; Taous Khan; Rahim Ullah; Muhammad Shahid; Ameer Khusro; Veronique Seidel; Magda H Abdellattif; Talha Bin Emran
Journal:  Evid Based Complement Alternat Med       Date:  2022-03-28       Impact factor: 2.629

9.  Green synthesis of silver nanoparticles through reduction with Solanum xanthocarpum L. berry extract: characterization, antimicrobial and urease inhibitory activities against Helicobacter pylori.

Authors:  Muhammad Amin; Farooq Anwar; Muhammad Ramzan Saeed Ashraf Janjua; Muhammad Awais Iqbal; Umer Rashid
Journal:  Int J Mol Sci       Date:  2012-08-09       Impact factor: 6.208

10.  Pharmacological basis for the use of Hypericum oblongifolium as a medicinal plant in the management of pain, inflammation and pyrexia.

Authors:  Naila Raziq; Muhammad Saeed; Muhammad Shahid; Naveed Muhammad; Haroon Khan; Farah Gul
Journal:  BMC Complement Altern Med       Date:  2016-02-01       Impact factor: 3.659
  10 in total

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