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Literature DB >> 20221784

Mitotic force generators and chromosome segregation.

Gul Civelekoglu-Scholey¹, Jonathan M Scholey.

Abstract

The mitotic spindle uses dynamic microtubules and mitotic motors to generate the pico-Newton scale forces that are needed to drive the mitotic movements that underlie chromosome capture, alignment and segregation. Here, we consider the biophysical and molecular basis of force-generation for chromosome movements in the spindle, and, with reference to the Drosophila embryo mitotic spindle, we briefly discuss how mathematical modeling can complement experimental analysis to illuminate the mechanisms of chromosome-to-pole motility during anaphase A and spindle elongation during anaphase B.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Molecular Motor Proteins

Year: 2010 PMID： 20221784 PMCID： PMC2883081 DOI： 10.1007/s00018-010-0326-6

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261

145 in total

Review 1. The dynamic kinetochore-microtubule interface.

Authors: Helder Maiato; Jennifer DeLuca; E D Salmon; William C Earnshaw
Journal: J Cell Sci Date: 2004-11-01 Impact factor: 5.285

2. Force production by disassembling microtubules.

Authors: Ekaterina L Grishchuk; Maxim I Molodtsov; Fazly I Ataullakhanov; J Richard McIntosh
Journal: Nature Date: 2005-11-17 Impact factor: 49.962

3. Retrograde transport by the microtubule-associated protein MAP 1C.

Authors: B M Paschal; R B Vallee
Journal: Nature Date: 1987 Nov 12-18 Impact factor: 49.962

4. Structural studies on porcine brain tubulin in extended sheets.

Authors: R H Crepeau; B McEwen; G Dykes; S J Edelstein
Journal: J Mol Biol Date: 1977-10-25 Impact factor: 5.469

5. Cytoplasmic dynein is required for poleward chromosome movement during mitosis in Drosophila embryos.

Authors: D J Sharp; G C Rogers; J M Scholey
Journal: Nat Cell Biol Date: 2000-12 Impact factor: 28.824

6. The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles.

Authors: David T Miyamoto; Zachary E Perlman; Kendra S Burbank; Aaron C Groen; Timothy J Mitchison
Journal: J Cell Biol Date: 2004-12-06 Impact factor: 10.539

7. Cross-sectional structure of the central mitotic spindle of Diatoma vulgare. Evidence for specific interactions between antiparallel microtubules.

Authors: K L McDonald; M K Edwards; J R McIntosh
Journal: J Cell Biol Date: 1979-11 Impact factor: 10.539

8. The mechanism of action of colchicine. Binding of colchincine-3H to cellular protein.

Authors: G G Borisy; E W Taylor
Journal: J Cell Biol Date: 1967-08 Impact factor: 10.539

9. Mitotic centromere-associated kinesin is important for anaphase chromosome segregation.

Authors: T Maney; A W Hunter; M Wagenbach; L Wordeman
Journal: J Cell Biol Date: 1998-08-10 Impact factor: 10.539

10. Quantitative analysis of an anaphase B switch: predicted role for a microtubule catastrophe gradient.

Authors: Dhanya K Cheerambathur; Gul Civelekoglu-Scholey; Ingrid Brust-Mascher; Patrizia Sommi; Alex Mogilner; Jonathan M Scholey
Journal: J Cell Biol Date: 2007-06-18 Impact factor: 10.539

35 in total

Review 1. Biophysics of mitosis.

Authors: J Richard McIntosh; Maxim I Molodtsov; Fazly I Ataullakhanov
Journal: Q Rev Biophys Date: 2012-02-10 Impact factor: 5.318

Mitotic force generators and chromosome segregation.

Review 1. The dynamic kinetochore-microtubule interface.

2. Force production by disassembling microtubules.

3. Retrograde transport by the microtubule-associated protein MAP 1C.

4. Structural studies on porcine brain tubulin in extended sheets.

5. Cytoplasmic dynein is required for poleward chromosome movement during mitosis in Drosophila embryos.

6. The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles.

7. Cross-sectional structure of the central mitotic spindle of Diatoma vulgare. Evidence for specific interactions between antiparallel microtubules.

8. The mechanism of action of colchicine. Binding of colchincine-3H to cellular protein.

9. Mitotic centromere-associated kinesin is important for anaphase chromosome segregation.

10. Quantitative analysis of an anaphase B switch: predicted role for a microtubule catastrophe gradient.

Review 1. Biophysics of mitosis.

2. Mitotic membrane helps to focus and stabilize the mitotic spindle.

Review 3. Unconventional functions of microtubule motors.

4. 50 ways to build a spindle: the complexity of microtubule generation during mitosis.

5. Multi-talented MCAK: Microtubule depolymerizer with a strong grip.

6. Theory of Cytoskeletal Reorganization during Cross-Linker-Mediated Mitotic Spindle Assembly.

7. Control of MCAK degradation and removal from centromeres.

8. An improved optical tweezers assay for measuring the force generation of single kinesin molecules.

9. Reconstitution of Basic Mitotic Spindles in Spherical Emulsion Droplets.

10. Eg5 restricts anaphase B spindle elongation in mammalian cells.