Literature DB >> 20218627

Efficient assembly of 2,5,6-substituted pyrimidines via MgI(2)-mediated Morita-Baylis-Hillman reaction.

Vasudha Sharma1, Mark L McLaughlin.   

Abstract

A mild and efficient protocol for the synthesis of a 2,6-disubstituted pyrimidine-5-carboxylate library via a Morita-Baylis-Hillman (MBH) adduct is described. Herein, the three step methodology involves the use of substituted alpha-iodomethylene beta-keto ester intermediates obtained after oxidation of the MBH adducts, which are condensed with various types of amidine or guanidine derivatives, to generate the 2, 6-disubstituted pyrimidines-5-carboxylate libraries.

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Year:  2010        PMID： 20218627      PMCID： PMC2919067          DOI： 10.1021/cc100001e

Source DB:  PubMed          Journal:  J Comb Chem        ISSN： 1520-4766


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