PURPOSE OF REVIEW: The aim is to review briefly the problems related to treatment of drug-susceptible and drug-resistant tuberculosis (TB), describe recent advances in the development of new drugs and new regimens, and discuss implications for control programmes. RECENT FINDINGS: Encouraging advances in TB drug research and development have been made since the turn of the century, resulting in a large number of new products introduced into the global portfolio. SUMMARY: Currently, nine compounds at least have advanced to clinical development, including four existing drugs redeveloped for TB indication and five new chemical entities. Present clinical trials are testing new combinations of drugs for a shortened treatment of drug-susceptible TB (<6 months duration) or the safety and efficacy of new drugs in addition to an optimized background therapy for the treatment of multidrug-resistant TB. There are at least 34 compounds or projects in the discovery and preclinical stages, including eight compounds in preclinical development. This increasing development of single compounds underscores the needs for a novel approach to test for optimal drug combinations that would be proposed for treatment of TB in all its forms, and the necessary collaboration of pharmaceutical companies, academia, research institutions, donors, and regulatory authorities.
PURPOSE OF REVIEW: The aim is to review briefly the problems related to treatment of drug-susceptible and drug-resistant tuberculosis (TB), describe recent advances in the development of new drugs and new regimens, and discuss implications for control programmes. RECENT FINDINGS: Encouraging advances in TB drug research and development have been made since the turn of the century, resulting in a large number of new products introduced into the global portfolio. SUMMARY: Currently, nine compounds at least have advanced to clinical development, including four existing drugs redeveloped for TB indication and five new chemical entities. Present clinical trials are testing new combinations of drugs for a shortened treatment of drug-susceptible TB (<6 months duration) or the safety and efficacy of new drugs in addition to an optimized background therapy for the treatment of multidrug-resistant TB. There are at least 34 compounds or projects in the discovery and preclinical stages, including eight compounds in preclinical development. This increasing development of single compounds underscores the needs for a novel approach to test for optimal drug combinations that would be proposed for treatment of TB in all its forms, and the necessary collaboration of pharmaceutical companies, academia, research institutions, donors, and regulatory authorities.
Authors: Yuri V Efremenko; Dmytro A Butov; Natalia D Prihoda; Svetlana I Zaitzeva; Larisa V Yurchenko; Nina I Sokolenko; Tetyana S Butova; Anna L Stepanenko; Galyna A Kutsyna; Vichai Jirathitikal; Aldar S Bourinbaiar Journal: Hum Vaccin Immunother Date: 2013-06-19 Impact factor: 3.452
Authors: Vadim Molodtsov; Nathan T Scharf; Maxwell A Stefan; George A Garcia; Katsuhiko S Murakami Journal: Mol Microbiol Date: 2017-01-10 Impact factor: 3.501
Authors: Anne F Luetkemeyer; Haileyesus Getahun; Gabriel Chamie; Christian Lienhardt; Diane V Havlir Journal: Am J Respir Crit Care Med Date: 2011-08-25 Impact factor: 21.405
Authors: Vadim Molodtsov; Irosha N Nawarathne; Nathan T Scharf; Paul D Kirchhoff; H D Hollis Showalter; George A Garcia; Katsuhiko S Murakami Journal: J Med Chem Date: 2013-05-31 Impact factor: 7.446