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Literature DB >> 20211749

A view from Drosophila: multiple biological functions for individual microRNAs.

Abstract

microRNAs (miRNAs) comprise an extensive class of post-transcriptional regulatory molecules in higher eukaryotes. Intensive research in Drosophila has revealed that miRNAs control myriad developmental and physiological processes. Interestingly, several of the best-studied miRNAs impact multiple biological processes, often by regulating distinct key target genes in each setting. Here we discuss the roles of some of these pleiotropic miRNAs, and their implications for studying and interpreting the roles of miRNAs in gene regulatory networks. (c) 2010 Elsevier Ltd. All rights reserved.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
MicroRNAs

Year: 2010 PMID： 20211749 PMCID： PMC2919623 DOI： 10.1016/j.semcdb.2010.03.001

Source DB: PubMed Journal: Semin Cell Dev Biol ISSN： 1084-9521 Impact factor: 7.727

81 in total

Review 1. Control of protein synthesis and mRNA degradation by microRNAs.

Authors: Jidong Liu
Journal: Curr Opin Cell Biol Date: 2008-03-10 Impact factor: 8.382

2. Functional genomic analysis of the Wnt-wingless signaling pathway.

Authors: Ramanuj DasGupta; Ajamete Kaykas; Randall T Moon; Norbert Perrimon
Journal: Science Date: 2005-04-07 Impact factor: 47.728

3. Regulation of Drosophila neurogenesis by RNA:RNA duplexes?

Authors: E C Lai; J W Posakony
Journal: Cell Date: 1998-06-26 Impact factor: 41.582

4. Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals.

Authors: Xiaohui Xie; Jun Lu; E J Kulbokas; Todd R Golub; Vamsi Mootha; Kerstin Lindblad-Toh; Eric S Lander; Manolis Kellis
Journal: Nature Date: 2005-02-27 Impact factor: 49.962

5. Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K.

Authors: Seogang Hyun; Jung Hyun Lee; Hua Jin; JinWu Nam; Bumjin Namkoong; Gina Lee; Jongkyeong Chung; V Narry Kim
Journal: Cell Date: 2009-12-11 Impact factor: 41.582

6. Maelstrom, a Drosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage.

Authors: Seth D Findley; Mio Tamanaha; Nigel J Clegg; Hannele Ruohola-Baker
Journal: Development Date: 2003-03 Impact factor: 6.868

7. The microRNA miR-8 is a conserved negative regulator of Wnt signaling.

Authors: Jennifer A Kennell; Isabelle Gerin; Ormond A MacDougald; Ken M Cadigan
Journal: Proc Natl Acad Sci U S A Date: 2008-09-29 Impact factor: 11.205

8. The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila.

Authors: Janina S Karres; Valérie Hilgers; Ines Carrera; Jessica Treisman; Stephen M Cohen
Journal: Cell Date: 2007-10-05 Impact factor: 41.582

9. Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function.

Authors: M Milán; F J Diaz-Benjumea; S M Cohen
Journal: Genes Dev Date: 1998-09-15 Impact factor: 11.361

10. Transgenic microRNA inhibition with spatiotemporal specificity in intact organisms.

Authors: Carlos M Loya; Cecilia S Lu; David Van Vactor; Tudor A Fulga
Journal: Nat Methods Date: 2009-11-15 Impact factor: 28.547

23 in total

1. A genome-wide transgenic resource for conditional expression of Drosophila microRNAs.

Authors: Fernando Bejarano; Diane Bortolamiol-Becet; Qi Dai; Kailiang Sun; Abil Saj; Yu-Ting Chou; David R Raleigh; Kevin Kim; Jian-Quan Ni; Hong Duan; Jr-Shiuan Yang; Tudor A Fulga; David Van Vactor; Norbert Perrimon; Eric C Lai
Journal: Development Date: 2012-06-28 Impact factor: 6.868

A view from Drosophila: multiple biological functions for individual microRNAs.

Review 1. Control of protein synthesis and mRNA degradation by microRNAs.

2. Functional genomic analysis of the Wnt-wingless signaling pathway.

3. Regulation of Drosophila neurogenesis by RNA:RNA duplexes?

4. Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals.

5. Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K.

6. Maelstrom, a Drosophila spindle-class gene, encodes a protein that colocalizes with Vasa and RDE1/AGO1 homolog, Aubergine, in nuage.

7. The microRNA miR-8 is a conserved negative regulator of Wnt signaling.

8. The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila.

9. Beadex encodes an LMO protein that regulates Apterous LIM-homeodomain activity in Drosophila wing development: a model for LMO oncogene function.

10. Transgenic microRNA inhibition with spatiotemporal specificity in intact organisms.

1. A genome-wide transgenic resource for conditional expression of Drosophila microRNAs.

2. Conserved microRNA miR-8 blocks activation of the Toll pathway by upregulating Serpin 27 transcripts.

Review 3. Hox miRNA regulation within the Drosophila Bithorax complex: Patterning behavior.

Review 4. Exploiting Drosophila genetics to understand microRNA function and regulation.

5. Functional characterization of Drosophila microRNAs by a novel in vivo library.

6. The microRNA miR-8 is a positive regulator of pigmentation and eclosion in Drosophila.

7. The mir-279/996 cluster represses receptor tyrosine kinase signaling to determine cell fates in the Drosophila eye.

Review 8. Adult-specific functions of animal microRNAs.

9. microRNA miR-275 is indispensable for blood digestion and egg development in the mosquito Aedes aegypti.

10. A new strategy for identification of highly conserved microRNAs in non-model insect, Spodoptera litura.