Literature DB >> 20210918

Distribution of killer cell immunoglobulin-like receptor genes in the mestizo population from Venezuela.

A Conesa1, M Fernández-Mestre, D Padrón, F Toro, N Silva, P Tassinari, I Blanca, M P Martin, M Carrington, Z Layrisse.   

Abstract

This study represents the first report on the distribution of KIR genes in 205 unrelated healthy mestizo Venezuelan individuals. Genotyping analysis showed that all KIR genes are present in this population. Frequency of inhibitory killer cell immunoglobulin-like receptors (KIRs) exceeded 0.69, except for KIR2DL2 (0.29) and 2DL5 (0.37). Activating KIRs showed low frequencies (0.11-0.29), except for KIR2DS4 (0.68). Forty-five different KIR genotypes were identified, with a predominance of three genotypes found in 50.7% of the population of which 25.9% were individuals homozygous for haplotype A. The frequencies of KIR genes reflect the ethnic admixture existing in the mestizo Venezuelan population.

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Year:  2010        PMID： 20210918      PMCID： PMC7366394          DOI： 10.1111/j.1399-0039.2010.01446.x

Source DB:  PubMed          Journal:  Tissue Antigens        ISSN： 0001-2815


  37 in total

1.  Killer Ig-like receptor haplotype analysis by gene content: evidence for genomic diversity with a minimum of six basic framework haplotypes, each with multiple subsets.

Authors:  Katharine C Hsu; Xiao-Rong Liu; Annamalai Selvakumar; Eric Mickelson; Richard J O'Reilly; Bo Dupont
Journal:  J Immunol       Date:  2002-11-01       Impact factor: 5.422

2.  KIR gene in ethnic and Mestizo populations from Mexico.

Authors:  M E Gutiérrez-Rodríguez; L Sandoval-Ramírez; M Díaz-Flores; S G E Marsh; A Valladares-Salgado; J A Madrigal; J M Mejía-Arangure; C A García; A Huerta-Zepeda; B Ibarra-Cortés; C Ortega-Camarillo; M Cruz
Journal:  Hum Immunol       Date:  2006-03-30       Impact factor: 2.850

3.  Amazonian Amerindians exhibit high variability of KIR profiles.

Authors:  Paloma Daguer Ewerton; Mauro de Meira Leite; Milena Magalhães; Leonardo Sena; Eduardo José Melo dos Santos
Journal:  Immunogenetics       Date:  2007-06-06       Impact factor: 2.846

4.  High KIR diversity in Amerindians is maintained using few gene-content haplotypes.

Authors:  Ketevan Gendzekhadze; Paul J Norman; Laurent Abi-Rached; Zulay Layrisse; Peter Parham
Journal:  Immunogenetics       Date:  2006-05-05       Impact factor: 2.846

5.  A human killer inhibitory receptor specific for HLA-A1,2.

Authors:  C Döhring; D Scheidegger; J Samaridis; M Cella; M Colonna
Journal:  J Immunol       Date:  1996-05-01       Impact factor: 5.422

6.  Genotyping of human killer-cell immunoglobulin-like receptor genes by polymerase chain reaction with sequence-specific primers: an update.

Authors:  N Gómez-Lozano; Carlos Vilches
Journal:  Tissue Antigens       Date:  2002-03

7.  A human histocompatibility leukocyte antigen (HLA)-G-specific receptor expressed on all natural killer cells.

Authors:  S Rajagopalan; E O Long
Journal:  J Exp Med       Date:  1999-04-05       Impact factor: 14.307

8.  KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C.

Authors:  Thorsten Graef; Achim K Moesta; Paul J Norman; Laurent Abi-Rached; Luca Vago; Anastazia M Older Aguilar; Michael Gleimer; John A Hammond; Lisbeth A Guethlein; David A Bushnell; Philip J Robinson; Peter Parham
Journal:  J Exp Med       Date:  2009-10-26       Impact factor: 14.307

9.  Plasticity in the organization and sequences of human KIR/ILT gene families.

Authors:  M J Wilson; M Torkar; A Haude; S Milne; T Jones; D Sheer; S Beck; J Trowsdale
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-25       Impact factor: 11.205

10.  Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes.

Authors:  Galit Alter; Maureen P Martin; Nickolas Teigen; William H Carr; Todd J Suscovich; Arne Schneidewind; Hendrik Streeck; Michael Waring; Angela Meier; Christian Brander; Jeffrey D Lifson; Todd M Allen; Mary Carrington; Marcus Altfeld
Journal:  J Exp Med       Date:  2007-11-19       Impact factor: 14.307
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