| Literature DB >> 8617928 |
C Döhring1, D Scheidegger, J Samaridis, M Cella, M Colonna.
Abstract
Killer inhibitory receptors (KIRs) are transmembrane glycoproteins, expressed on NK cells and a small subset of T cells, that inhibit cell-mediated cytotoxicity upon binding to polymorphic MHC class I determinants on target cells. Although human KIRs specific for HLA-C and HLA-B molecules have been characterized, none have been shown to interact with HLA-A. Here we demonstrate that a member of the KIR cDNA family, designated NKAT4, encodes a 70-kDa receptor specific for HLA-A3.Entities:
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Year: 1996 PMID: 8617928
Source DB: PubMed Journal: J Immunol ISSN: 0022-1767 Impact factor: 5.422