Literature DB >> 20209002

Isolation and characterization of antineoplastic alkaloids from Catharanthus roseus L. Don. cultivated in Egypt.

Khaled A Shams1, Naglaa M Nazif, Nahla S Abdel Azim, Khaled A Abdel Shafeek, Mostafa M El-Missiry, Shams I Ismail, Medhat M Seif El Nasr.   

Abstract

Vinblastine and vincristine (the antileukemic agents) were isolated, in a pure form, from Catharanthus roseus L. Don., cultivated in Egypt, by several chromatographic techniques. Five modified methods for the preparation of total alkaloids were carried out. All the isolated mixtures were evaluated by HPLC and HPTLC analyses. The antineoplastic alkaloids; vinblastine and vincristine, were isolated by the use of vacuum liquid chromatographic column on silica gel : aluminium oxide (1:1) mixed bed vacuum liquid chromatography (VLC), Charcoal column, and finally purified by centrifugally accelerated radial chromatography (Chromatotrone).

Entities:  

Keywords:  Antileuckemic alkaloids; Apocyanaceae; Catharanthus roseus L.; HPLC; HPTLC; VLC; Vinblastine; Vincrisitine

Mesh：

Substances：

Year:  2009        PMID： 20209002      PMCID： PMC2816563          DOI： 10.4314/ajtcam.v6i2.57082

Source DB:  PubMed          Journal:  Afr J Tradit Complement Altern Med        ISSN： 2505-0044


  7 in total

1.  Isolation of indole alkaloids from Catharanthus roseus by centrifugal partition chromatography in the pH-zone refining mode.

Authors:  J H Renault; J M Nuzillard; G Le Crouérour; P Thépenier; M Zèches-Hanrot; L Le Men-Olivier
Journal:  J Chromatogr A       Date:  1999-07-23       Impact factor: 4.759

2.  Monitoring the production yields of vincristine and vinblastine in Catharanthus roseus from somatic embryogenesis. Semiquantitative determination by flow-injection electrospray ionization mass spectrometry.

Authors:  D Favretto; A Piovan; R Filippini; R Caniato
Journal:  Rapid Commun Mass Spectrom       Date:  2001       Impact factor: 2.419

Review 3.  Alkaloid accumulation in Catharanthus roseus suspension cultures.

Authors:  A H Scragg
Journal:  Methods Mol Biol       Date:  1999

4.  A rapid procedure for the isolation of Catharanthine, vindoline and vinblastine.

Authors:  M Bashir; M Hafeez; N Perveen; J Fatima; A N Mistry
Journal:  Planta Med       Date:  1983-04       Impact factor: 3.352

5.  Identification of indole alkaloids of Catharanthus roseus with liquid chromatography/mass spectrometry using collision-induced dissociation with the thermospray ion repeller.

Authors:  S Auriola; T Naaranlahti; R Kostiainen; S P Lapinjoki
Journal:  Biomed Environ Mass Spectrom       Date:  1990-07

6.  Effect of terpenoid precursor feeding and elicitation on formation of indole alkaloids in cell suspension cultures of Catharanthus roseus.

Authors:  P R Moreno; R van der Heijden; R Verpoorte
Journal:  Plant Cell Rep       Date:  1993-10       Impact factor: 4.570

7.  Isolation and 13C-NMR Studies on Cathovaline, an Alkaloid from the Leaves of Catharanthus roseus.

Authors:  I Ali; M I Chaudhry
Journal:  Planta Med       Date:  1985-10       Impact factor: 3.352
  7 in total
  5 in total

1.  Cedrus atlantica extract exerts antiproliferative effect on colorectal cancer through the induction of cell cycle arrest and apoptosis.

Authors:  Chih-Yuan Huang; Ju-Huei Chien; Kai-Fu Chang; Chih-Yen Hsiao; Ya-Chih Huang; Yi-Ting Chen; Ming-Yi Hsu; Ming-Chang Hsieh; Nu-Man Tsai
Journal:  Food Sci Nutr       Date:  2022-02-21       Impact factor: 3.553

Review 2.  Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation.

Authors:  Wamidh H Talib; Izzeddin Alsalahat; Safa Daoud; Reem Fawaz Abutayeh; Asma Ismail Mahmod
Journal:  Molecules       Date:  2020-11-14       Impact factor: 4.411

3.  Fungal vincristine from Eutypella spp - CrP14 isolated from Catharanthus roseus induces apoptosis in human squamous carcinoma cell line -A431.

Authors:  Gini C Kuriakose; Padmini P C Palem; Chelliah Jayabaskaran
Journal:  BMC Complement Altern Med       Date:  2016-08-22       Impact factor: 3.659

4.  An Endophytic Fungus, Talaromyces radicus, Isolated from Catharanthus roseus, Produces Vincristine and Vinblastine, Which Induce Apoptotic Cell Death.

Authors:  Padmini P C Palem; Gini C Kuriakose; Chelliah Jayabaskaran
Journal:  PLoS One       Date:  2015-12-23       Impact factor: 3.240

5.  Development of a Cell Suspension Culture System for Promoting Alkaloid and Vinca Alkaloid Biosynthesis Using Endophytic Fungi Isolated from Local Catharanthus roseus.

Authors:  Tran My Linh; Nguyen Chi Mai; Pham Thi Hoe; Ninh Thi Ngoc; Phan Thi Hong Thao; Ninh Khac Ban; Nguyen Tuong Van
Journal:  Plants (Basel)       Date:  2021-03-31
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.