Literature DB >> 20208164

Crystallization of community-acquired respiratory distress syndrome toxin from Mycoplasma pneumoniae.

Olga N Pakhomova1, Alexander B Taylor, Argentina Becker, Stephen P Holloway, T R Kannan, Joel B Baseman, P John Hart.   

Abstract

Community-acquired respiratory distress syndrome toxin (CARDS TX) is a 591-amino-acid protein with ADP-ribosyltransferase and vacuolating activities that damages the cells lining the respiratory tracts of patients infected with the bacterial pathogen Mycoplasma pneumoniae. Crystals of CARDS TX were grown in space group C2, with unit-cell parameters a = 191.4, b = 107.4, c = 222.1 A, beta = 90.6 degrees. A complete 2.2 A data set was obtained from a single CARDS TX crystal.

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Year:  2010        PMID： 20208164      PMCID： PMC2833040          DOI： 10.1107/S1744309110000114

Source DB:  PubMed          Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun        ISSN： 1744-3091


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1.  Structure of CARDS toxin, a unique ADP-ribosylating and vacuolating cytotoxin from Mycoplasma pneumoniae.

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3.  Functional mapping of community-acquired respiratory distress syndrome (CARDS) toxin of Mycoplasma pneumoniae defines regions with ADP-ribosyltransferase, vacuolating and receptor-binding activities.

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