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Literature DB >> 20208031

Heterologous expression of the oxytetracycline biosynthetic pathway in Myxococcus xanthus.

D Cole Stevens¹, Michael R Henry, Kimberly A Murphy, Christopher N Boddy.

Abstract

New natural products for drug discovery may be accessed by heterologous expression of bacterial biosynthetic pathways in metagenomic DNA libraries. However, a "universal" host is needed for this experiment. Herein, we show that Myxococcus xanthus is a potential "universal" host for heterologous expression of polyketide biosynthetic gene clusters.

Entities: Chemical Species

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Year: 2010 PMID： 20208031 PMCID： PMC2849223 DOI： 10.1128/AEM.02841-09

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

24 in total

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Authors: Aurélien Ginolhac; Cyrille Jarrin; Benjamin Gillet; Patrick Robe; Petar Pujic; Karine Tuphile; Hélène Bertrand; Timothy M Vogel; Guy Perrière; Pascal Simonet; Renaud Nalin
Journal: Appl Environ Microbiol Date: 2004-09 Impact factor: 4.792

Review 2. Polyketide and nonribosomal peptide antibiotics: modularity and versatility.

Authors: Christopher T Walsh
Journal: Science Date: 2004-03-19 Impact factor: 47.728

3. Effects of growth medium, inoculum size, and incubation time on culturability and isolation of soil bacteria.

Authors: Kathryn E R Davis; Shayne J Joseph; Peter H Janssen
Journal: Appl Environ Microbiol Date: 2005-02 Impact factor: 4.792

4. Cloning and heterologous expression of the epothilone gene cluster.

Authors: L Tang; S Shah; L Chung; J Carney; L Katz; C Khosla; B Julien
Journal: Science Date: 2000-01-28 Impact factor: 47.728

Review 5. Measurement of in situ activities of nonphotosynthetic microorganisms in aquatic and terrestrial habitats.

Authors: J T Staley; A Konopka
Journal: Annu Rev Microbiol Date: 1985 Impact factor: 15.500

6. Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via red/ET recombineering.

Authors: Silke C Wenzel; Frank Gross; Youming Zhang; Jun Fu; A Francis Stewart; Rolf Müller
Journal: Chem Biol Date: 2005-03

7. Evidence that asgB encodes a DNA-binding protein essential for growth and development of Myxococcus xanthus.

Authors: L Plamann; J M Davis; B Cantwell; J Mayor
Journal: J Bacteriol Date: 1994-04 Impact factor: 3.490

8. Engineered biosynthesis of a complete macrolactone in a heterologous host.

Authors: C M Kao; L Katz; C Khosla
Journal: Science Date: 1994-07-22 Impact factor: 47.728

Review 9. Myxobacteria: proficient producers of novel natural products with various biological activities--past and future biotechnological aspects with the focus on the genus Sorangium.

Authors: Klaus Gerth; Silke Pradella; Olena Perlova; Stefan Beyer; Rolf Müller
Journal: J Biotechnol Date: 2003-12-19 Impact factor: 3.307

10. Rapid cloning and heterologous expression of the meridamycin biosynthetic gene cluster using a versatile Escherichia coli-streptomyces artificial chromosome vector, pSBAC.

Authors: Hongbo Liu; Hao Jiang; Bradley Haltli; Kerry Kulowski; Elwira Muszynska; Xidong Feng; Mia Summers; Mairead Young; Edmund Graziani; Frank Koehn; Guy T Carter; Min He
Journal: J Nat Prod Date: 2009-03-27 Impact factor: 4.050

13 in total

1. Engineering Pseudochelin Production in Myxococcus xanthus.

Authors: Juliane Korp; Lea Winand; Angela Sester; Markus Nett
Journal: Appl Environ Microbiol Date: 2018-10-30 Impact factor: 4.792

Review 2. Synthetic biology of antimicrobial discovery.

Authors: Bijan Zakeri; Timothy K Lu
Journal: ACS Synth Biol Date: 2012-12-04 Impact factor: 5.110

Review 3. Oxytetracycline biosynthesis.

Authors: Lauren B Pickens; Yi Tang
Journal: J Biol Chem Date: 2010-06-03 Impact factor: 5.157

4. Heterologous expression and manipulation of three tetracycline biosynthetic pathways.

Authors: Peng Wang; Woncheol Kim; Lauren B Pickens; Xue Gao; Yi Tang
Journal: Angew Chem Int Ed Engl Date: 2012-09-28 Impact factor: 15.336

Review 5. Genetic platforms for heterologous expression of microbial natural products.

Authors: Jia Jia Zhang; Xiaoyu Tang; Bradley S Moore
Journal: Nat Prod Rep Date: 2019-06-14 Impact factor: 13.423

6. High-Titer Production of the Fungal Anhydrotetracycline, TAN-1612, in Engineered Yeasts.

Authors: Pedro A Baldera-Aguayo; Arden Lee; Virginia W Cornish
Journal: ACS Synth Biol Date: 2022-06-14 Impact factor: 5.249

7. MultiMetEval: comparative and multi-objective analysis of genome-scale metabolic models.

Authors: Piotr Zakrzewski; Marnix H Medema; Albert Gevorgyan; Andrzej M Kierzek; Rainer Breitling; Eriko Takano
Journal: PLoS One Date: 2012-12-14 Impact factor: 3.240

Review 8. Biotechnology of polyketides: new breath of life for the novel antibiotic genetic pathways discovery through metagenomics.

Authors: Elisângela Soares Gomes; Viviane Schuch; Eliana Gertrudes de Macedo Lemos
Journal: Braz J Microbiol Date: 2014-03-10 Impact factor: 2.476

9. Heterologous Production of the Marine Myxobacterial Antibiotic Haliangicin and Its Unnatural Analogues Generated by Engineering of the Biochemical Pathway.

Authors: Yuwei Sun; Zhiyang Feng; Tomohiko Tomura; Akira Suzuki; Seishi Miyano; Takashi Tsuge; Hitoshi Mori; Joo-Won Suh; Takashi Iizuka; Ryosuke Fudou; Makoto Ojika
Journal: Sci Rep Date: 2016-02-26 Impact factor: 4.379

10. Alternative sigma factor over-expression enables heterologous expression of a type II polyketide biosynthetic pathway in Escherichia coli.

Authors: David Cole Stevens; Kyle R Conway; Nelson Pearce; Luis Roberto Villegas-Peñaranda; Anthony G Garza; Christopher N Boddy
Journal: PLoS One Date: 2013-05-28 Impact factor: 3.240