Literature DB >> 20207180

(13)C hyperpolarization of a barbituric acid derivative via parahydrogen induced polarization.

Meike Roth1, Achim Koch, Petra Kindervater, Joachim Bargon, Hans Wolfgang Spiess, Kerstin Münnemann.   

Abstract

Significant (13)C NMR signal enhancement by a factor of 5000 of a barbituric acid derivative (5-methyl-5-propenyl-barbituric acid) via parahydrogen induced polarization is presented. This hyperpolarization is achieved by hydrogenating 5-methyl-5-propargyl-barbituric acid with 98% enriched para-H(2) under elevated temperature and pressure and transferring the initially created (1)H hyperpolarization with an INEPT-derived pulse sequence to (13)C. The polarization can be selectively transferred to different carbons in the barbituric acid derivative by applying different pulse delays in the INEPT pulse sequence. These results demonstrate the potential of using hyperpolarized barbituric acid derivatives as "active" contrast agents in MRI and visualizing their pharmacokinetics in vivo. Copyright 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20207180     DOI： 10.1016/j.jmr.2010.01.016

Source DB:  PubMed          Journal:  J Magn Reson        ISSN： 1090-7807            Impact factor:   2.229


  6 in total

1.  NMR hyperpolarization techniques for biomedicine.

Authors:  Panayiotis Nikolaou; Boyd M Goodson; Eduard Y Chekmenev
Journal:  Chemistry       Date:  2014-12-03       Impact factor: 5.236

2.  Parahydrogen Induced Polarization with Rh-based Monodentate Ligand in Water.

Authors:  Roman V Shchepin; Aaron M Coffey; Kevin W Waddell; Eduard Y Chekmenev
Journal:  J Phys Chem Lett       Date:  2012-10-23       Impact factor: 6.475

3.  Quantitative analysis of molecular transport across liposomal bilayer by J-mediated 13C Overhauser dynamic nuclear polarization.

Authors:  Chi-Yuan Cheng; Olga J G M Goor; Songi Han
Journal:  Anal Chem       Date:  2012-10-23       Impact factor: 6.986

4.  Real-Time Interrogation of Aspirin Reactivity, Biochemistry, and Biodistribution by Hyperpolarized Magnetic Resonance Spectroscopy.

Authors:  Niki M Zacharias; Argentina Ornelas; Jaehyuk Lee; Jingzhe Hu; Jennifer S Davis; Nasir Uddin; Shivanand Pudakalakatti; David G Menter; Jose A Karam; Christopher G Wood; Ernest T Hawk; Scott Kopetz; Eduardo Vilar; Pratip K Bhattacharya; Steven W Millward
Journal:  Angew Chem Int Ed Engl       Date:  2019-02-20       Impact factor: 15.336

5.  Open-Source Automated Parahydrogen Hyperpolarizer for Molecular Imaging Using (13)C Metabolic Contrast Agents.

Authors:  Aaron M Coffey; Roman V Shchepin; Milton L Truong; Ken Wilkens; Wellington Pham; Eduard Y Chekmenev
Journal:  Anal Chem       Date:  2016-08-01       Impact factor: 6.986

6.  PHIP hyperpolarized [1-13C]pyruvate and [1-13C]acetate esters via PH-INEPT polarization transfer monitored by 13C NMR and MRI.

Authors:  Alexandra Svyatova; Vitaly P Kozinenko; Nikita V Chukanov; Dudari B Burueva; Eduard Y Chekmenev; Yu-Wen Chen; Dennis W Hwang; Kirill V Kovtunov; Igor V Koptyug
Journal:  Sci Rep       Date:  2021-03-11       Impact factor: 4.379
  6 in total

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