| Literature DB >> 20207018 |
Andrea De Laurentiis1, Javier Fernandez-Solari, Claudia Mohn, Berenice Burdet, María A Zorrilla Zubilete, Valeria Rettori.
Abstract
This study investigated the participation of the hypothalamic endocannabinoid system in the response to lipopolysaccharide (LPS) challenge evaluating oxytocin (OXT) and tumor necrosis factor-alpha (TNF-alpha) plasma levels in vivo and their release from hypothalamic fragments in vitro. LPS increased OXT and TNF-alpha release through anandamide-activation of hypothalamic cannabinoid receptor CB(1,) since the antagonist AM251 blocked this effect. Anandamide, through its receptors, also increased hypothalamic nitric oxide (NO) which inhibited OXT release, ending the stimulatory effect of the endocannabinoid. Our findings reveal a hypothalamic interaction between oxytocin, endocannabinoid and NO-ergic systems providing a regulation of the hypothalamic-neurohypophyseal axis under basal and stress conditions. Copyright 2010 Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20207018 DOI： 10.1016/j.jneuroim.2010.02.006
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478