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Literature DB >> 20200562

Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine.

H S Gill¹, J Söderholm, M R Prausnitz, M Sällberg.

Abstract

The skin is potentially an excellent organ for vaccine delivery because of accessibility and the presence of immune cells. However, no simple and inexpensive cutaneous vaccination method is available. Micron-scale needles coated with DNA were tested as a simple, inexpensive device for skin delivery. Vaccination with a plasmid encoding hepatitis C virus nonstructural 3/4A protein using microneedles effectively primed specific cytotoxic T lymphocytes (CTLs). Importantly, the minimally invasive microneedles were as efficient in priming CTLs as more complicated or invasive delivery techniques, such as gene gun and hypodermic needles. Thus, microneedles may offer a promising technology for DNA vaccination.

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Year: 2010 PMID： 20200562 PMCID： PMC2914565 DOI： 10.1038/gt.2010.22

Source DB: PubMed Journal: Gene Ther ISSN： 0969-7128 Impact factor: 5.250

17 in total

1. Improved genetic immunization via micromechanical disruption of skin-barrier function and targeted epidermal delivery.

Authors: John A Mikszta; Jason B Alarcon; John M Brittingham; Diane E Sutter; Ronald J Pettis; Noel G Harvey
Journal: Nat Med Date: 2002-04 Impact factor: 53.440

2. Macroflux microprojection array patch technology: a new and efficient approach for intracutaneous immunization.

Authors: James A Matriano; Michel Cormier; Juanita Johnson; Wendy A Young; Margaret Buttery; Kofi Nyam; Peter E Daddona
Journal: Pharm Res Date: 2002-01 Impact factor: 4.200

3. Cross-priming as a predominant mechanism for inducing CD8(+) T cell responses in gene gun DNA immunization.

Authors: J H Cho; J W Youn; Y C Sung
Journal: J Immunol Date: 2001-11-15 Impact factor: 5.422

4. Safety and efficacy of a novel microneedle device for dose sparing intradermal influenza vaccination in healthy adults.

Authors: Pierre Van Damme; Froukje Oosterhuis-Kafeja; Marie Van der Wielen; Yotam Almagor; Ofer Sharon; Yotam Levin
Journal: Vaccine Date: 2008-11-18 Impact factor: 3.641

Review 5. Microneedle-based vaccines.

Authors: Mark R Prausnitz; John A Mikszta; Michel Cormier; Alexander K Andrianov
Journal: Curr Top Microbiol Immunol Date: 2009 Impact factor: 4.291

Review 6. Technical and regulatory hurdles for DNA vaccines.

Authors: John Donnelly; Karin Berry; Jeffrey B Ulmer
Journal: Int J Parasitol Date: 2003-05 Impact factor: 3.981

7. Low dose and gene gun immunization with a hepatitis C virus nonstructural (NS) 3 DNA-based vaccine containing NS4A inhibit NS3/4A-expressing tumors in vivo.

Authors: L Frelin; M Alheim; A Chen; J Söderholm; B Rozell; C Barnfield; P Liljeström; M Sällberg
Journal: Gene Ther Date: 2003-04 Impact factor: 5.250

8. Codon optimization and mRNA amplification effectively enhances the immunogenicity of the hepatitis C virus nonstructural 3/4A gene.

Authors: L Frelin; G Ahlén; M Alheim; O Weiland; C Barnfield; P Liljeström; M Sällberg
Journal: Gene Ther Date: 2004-03 Impact factor: 5.250

9. Effect of microneedle design on pain in human volunteers.

Authors: Harvinder S Gill; Donald D Denson; Brett A Burris; Mark R Prausnitz
Journal: Clin J Pain Date: 2008-09 Impact factor: 3.442

10. Microneedles permit transdermal delivery of a skin-impermeant medication to humans.

Authors: Daniel P Wermeling; Stan L Banks; David A Hudson; Harvinder S Gill; Jyoti Gupta; Mark R Prausnitz; Audra L Stinchcomb
Journal: Proc Natl Acad Sci U S A Date: 2008-02-04 Impact factor: 11.205

45 in total

1. DNA vaccination in the skin using microneedles improves protection against influenza.

Authors: Jae-Min Song; Yeu-Chun Kim; Eunju O; Richard W Compans; Mark R Prausnitz; Sang-Moo Kang
Journal: Mol Ther Date: 2012-04-17 Impact factor: 11.454

2. Transdermal delivery devices: fabrication, mechanics and drug release from silk.

Authors: Waseem K Raja; Scott Maccorkle; Izzuddin M Diwan; Abdurrahman Abdurrob; Jessica Lu; Fiorenzo G Omenetto; David L Kaplan
Journal: Small Date: 2013-05-08 Impact factor: 13.281

Review 3. Microneedle Coating Methods: A Review with a Perspective.

Authors: Rohan S J Ingrole; Harvinder Singh Gill
Journal: J Pharmacol Exp Ther Date: 2019-06-07 Impact factor: 4.030

4. Intradermal vaccination with influenza virus-like particles by using microneedles induces protection superior to that with intramuscular immunization.

Authors: Fu-Shi Quan; Yeu-Chun Kim; Aswani Vunnava; Dae-Goon Yoo; Jae-Min Song; Mark R Prausnitz; Richard W Compans; Sang-Moo Kang
Journal: J Virol Date: 2010-05-19 Impact factor: 5.103