Literature DB >> 20198226

A small molecule receptor that selectively recognizes trimethyl lysine in a histone peptide with native protein-like affinity.

Lindsey A Ingerman1, Matthew E Cuellar, Marcey L Waters.   

Abstract

A small molecule receptor that mimics the HP1 chromodomain's affinity for trimethyl lysine has been identified from a dynamic combinatorial library. Discrimination for trimethyl lysine over the lower methylation states parallels that of the native protein receptor. These studies demonstrate the feasibility of small molecule receptors as potential sensors for protein post-translational modifications.

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Year:  2010        PMID： 20198226     DOI： 10.1039/c000255k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  13 in total

1.  Site-Selective Sensing of Histone Methylation Enzyme Activity via an Arrayed Supramolecular Tandem Assay.

Authors:  Yang Liu; Lizeth Perez; Adam D Gill; Magi Mettry; Lin Li; Yinsheng Wang; Richard J Hooley; Wenwan Zhong
Journal:  J Am Chem Soc       Date:  2017-08-08       Impact factor: 15.419

Review 2.  Histones: at the crossroads of peptide and protein chemistry.

Authors:  Manuel M Müller; Tom W Muir
Journal:  Chem Rev       Date:  2014-10-20       Impact factor: 60.622

3.  Protein camouflage in cytochrome c-calixarene complexes.

Authors:  Róise E McGovern; Humberto Fernandes; Amir R Khan; Nicholas P Power; Peter B Crowley
Journal:  Nat Chem       Date:  2012-04-29       Impact factor: 24.427

4.  Late stage modification of receptors identified from dynamic combinatorial libraries.

Authors:  Nicholas K Pinkin; Amanie N Power; Marcey L Waters
Journal:  Org Biomol Chem       Date:  2015-09-18       Impact factor: 3.876

5.  Cation-π interactions of methylated ammonium ions: a quantum mechanical study.

Authors:  Chaya Rapp; Elizabeth Goldberger; Nasim Tishbi; Rachel Kirshenbaum
Journal:  Proteins       Date:  2014-02-18

6.  Sensing of citrulline modifications in histone peptides by deep cavitand hosts.

Authors:  Adam D Gill; Briana L Hickey; Siwen Wang; Min Xue; Wenwan Zhong; Richard J Hooley
Journal:  Chem Commun (Camb)       Date:  2019-10-31       Impact factor: 6.222

7.  Labeled protein recognition at a membrane bilayer interface by embedded synthetic receptors.

Authors:  Yoo-Jin Ghang; Jonathan J Lloyd; Melissa P Moehlig; Jessica K Arguelles; Magi Mettry; Xing Zhang; Ryan R Julian; Quan Cheng; Richard J Hooley
Journal:  Langmuir       Date:  2014-08-19       Impact factor: 3.882

8.  Structural study of a small molecule receptor bound to dimethyllysine in lysozyme.

Authors:  Róise E McGovern; Brendan D Snarr; Joseph A Lyons; James McFarlane; Amanda L Whiting; Irina Paci; Fraser Hof; Peter B Crowley
Journal:  Chem Sci       Date:  2015-01-01       Impact factor: 9.825

9.  Site selective reading of epigenetic markers by a dual-mode synthetic receptor array.

Authors:  Yang Liu; Lizeth Perez; Magi Mettry; Adam D Gill; Samantha R Byers; Connor J Easley; Christopher J Bardeen; Wenwan Zhong; Richard J Hooley
Journal:  Chem Sci       Date:  2017-03-22       Impact factor: 9.825

10.  The dark side of disulfide-based dynamic combinatorial chemistry.

Authors:  Mélissa Dumartin; Jean Septavaux; Marion Donnier-Maréchal; Emeric Jeamet; Elise Dumont; Florent Perret; Laurent Vial; Julien Leclaire
Journal:  Chem Sci       Date:  2020-07-17       Impact factor: 9.825
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