Literature DB >> 20196543

Oligooxopiperazines as nonpeptidic alpha-helix mimetics.

Petra Tosovská1, Paramjit S Arora.   

Abstract

A new class of nonpeptidic alpha-helix mimetics derived from alpha-amino acids and featuring chiral backbones is described. NMR and circular dichroism spectroscopies, in combination with molecular modeling studies, provide compelling evidence that oligooxopiperazine dimers adopt stable conformations that reproduce the arrangement of i, i+4, and i+7 residues on an alpha-helix.

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Year:  2010        PMID： 20196543     DOI： 10.1021/ol1003143

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  25 in total

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Review 10.  Protein Domain Mimics as Modulators of Protein-Protein Interactions.

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