CONTEXT: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is bound predominately to low-density lipoprotein and has been implicated as a risk factor for coronary artery disease (CAD). OBJECTIVE: We investigated the association between Lp-PLA(2) and CAD in a biethnic African-American and Caucasian population. DESIGN: Lp-PLA(2) mass, activity, and index, an integrated measure of mass and activity, and other cardiovascular risk factors were determined in 224 African-Americans and 336 Caucasians undergoing coronary angiography. MAIN OUTCOME MEASURES: We assessed the distribution of Lp-PLA(2) levels and determined the predictive role of Lp-PLA(2) as a risk factor for CAD. RESULTS: Levels of Lp-PLA(2) mass and activity were higher among Caucasians compared with African-Americans (293 +/- 75 vs. 232 +/- 76 ng/ml, P < 0.001 for mass and 173 +/- 41 vs. 141 +/- 39 nmol/min/ml, P < 0.001 for activity, respectively). However, Lp-PLA(2) index was similar in the two groups (0.61 +/- 0.17 vs. 0.64 +/- 0.19, P = NS). In both ethnic groups, Lp-PLA(2) activity and index was significantly higher among subjects with CAD. African-American subjects with CAD had significantly higher Lp-PLA(2) index than corresponding Caucasian subjects (0.69 +/- 0.20 vs. 0.63 +/- 0.18, P = 0.028). In multivariate regression analyses, after adjusting for other risk factors, Lp-PLA(2) index was independently (odds ratio 6.7, P = 0.047) associated with CAD in African-Americans but not Caucasians. CONCLUSIONS: Lp-PLA(2) activity and index was associated with presence of CAD among African-Americans and Caucasians undergoing coronary angiography. The findings suggest an independent impact of vascular inflammation among African-Americans as contributory to CAD risk and underscore the importance of Lp-PLA(2) as a cardiovascular risk factor.
CONTEXT: Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is bound predominately to low-density lipoprotein and has been implicated as a risk factor for coronary artery disease (CAD). OBJECTIVE: We investigated the association between Lp-PLA(2) and CAD in a biethnic African-American and Caucasian population. DESIGN:Lp-PLA(2) mass, activity, and index, an integrated measure of mass and activity, and other cardiovascular risk factors were determined in 224 African-Americans and 336 Caucasians undergoing coronary angiography. MAIN OUTCOME MEASURES: We assessed the distribution of Lp-PLA(2) levels and determined the predictive role of Lp-PLA(2) as a risk factor for CAD. RESULTS: Levels of Lp-PLA(2) mass and activity were higher among Caucasians compared with African-Americans (293 +/- 75 vs. 232 +/- 76 ng/ml, P < 0.001 for mass and 173 +/- 41 vs. 141 +/- 39 nmol/min/ml, P < 0.001 for activity, respectively). However, Lp-PLA(2) index was similar in the two groups (0.61 +/- 0.17 vs. 0.64 +/- 0.19, P = NS). In both ethnic groups, Lp-PLA(2) activity and index was significantly higher among subjects with CAD. African-American subjects with CAD had significantly higher Lp-PLA(2) index than corresponding Caucasian subjects (0.69 +/- 0.20 vs. 0.63 +/- 0.18, P = 0.028). In multivariate regression analyses, after adjusting for other risk factors, Lp-PLA(2) index was independently (odds ratio 6.7, P = 0.047) associated with CAD in African-Americans but not Caucasians. CONCLUSIONS:Lp-PLA(2) activity and index was associated with presence of CAD among African-Americans and Caucasians undergoing coronary angiography. The findings suggest an independent impact of vascular inflammation among African-Americans as contributory to CAD risk and underscore the importance of Lp-PLA(2) as a cardiovascular risk factor.
Authors: Erdembileg Anuurad; Jill Rubin; Guijing Lu; Thomas A Pearson; Steve Holleran; Rajasekhar Ramakrishnan; Lars Berglund Journal: J Lipid Res Date: 2006-08-03 Impact factor: 5.922
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Authors: Karl Winkler; Michael M Hoffmann; Bernhard R Winkelmann; Isolde Friedrich; Günther Schäfer; Ursula Seelhorst; Britta Wellnitz; Heinrich Wieland; Bernhard O Boehm; Winfried März Journal: Clin Chem Date: 2007-06-15 Impact factor: 8.327
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Authors: Shahar Lavi; Joseph P McConnell; Charanjit S Rihal; Abhiram Prasad; Verghese Mathew; Lilach O Lerman; Amir Lerman Journal: Circulation Date: 2007-05-14 Impact factor: 29.690
Authors: C Ballantyne; M Cushman; B Psaty; C Furberg; K T Khaw; M Sandhu; J Oldgren; G P Rossi; G Maiolino; M Cesari; L Lenzini; S K James; E Rimm; R Collins; J Anderson; W Koenig; H Brenner; D Rothenbacher; G Berglund; M Persson; P Berger; E Brilakis; J P McConnell; W Koenig; R Sacco; M Elkind; P Talmud; E Rimm; C P Cannon; C Packard; E Barrett-Connor; A Hofman; I Kardys; J C M Witteman; M Criqui; J P Corsetti; D L Rainwater; A J Moss; S Robins; H Bloomfield; D Collins; C Packard; S Wassertheil-Smoller; P Ridker; C Ballantyne; C P Cannon; M Cushman; J Danesh; D Gu; A Hofman; J J Nelson; S Thompson; A Zalewski; N Zariffa; E Di Angelantonio; S Kaptoge; A Thompson; S Thompson; M Walker; S Watson; A Wood Journal: Eur J Cardiovasc Prev Rehabil Date: 2007-02