OBJECTIVE: Apolipoprotein E (apoE) has been implicated as conveying increased risk for coronary artery disease (CAD). Previous studies suggest a role of apoE as a modulator of immune response and inflammatory properties. We hypothesized that the presence of apo E4 is associated with an increased inflammatory burden in subjects with CAD as compared to subjects without CAD. METHODS: ApoE genotypes, systemic (C-reactive protein [CRP], fibrinogen, serum amyloid-A [SAA]) and vascular inflammatory markers (Lipoprotein-associated phospholipase A(2) [Lp-PLA(2)] and pentraxin-3 [PTX-3]) were assessed in 324 Caucasians and 208 African Americans, undergoing coronary angiography. RESULTS: For both ethnic groups, Lp-PLA(2) index, an integrated measure of Lp-PLA(2) mass and activity, increased significantly and stepwise across apoE isoforms (P = 0.009 and P = 0.026 for African Americans and Caucasians respectively). No differences were found for other inflammatory markers tested (CRP, fibrinogen, SAA and PTX-3). For the top cardiovascular score tertile, apo E4 carriers had a significantly higher level of Lp-PLA(2) index in both ethnic groups (P = 0.027 and P = 0.010, respectively). CONCLUSION: The presence of the apo E4 isoform was associated with a higher level of Lp-PLA(2) index, a marker of vascular inflammation. Our results suggest that genetic variation at the apoE locus may impact cardiovascular disease risk through enhanced vascular inflammation. Published by Elsevier Ireland Ltd.
OBJECTIVE:Apolipoprotein E (apoE) has been implicated as conveying increased risk for coronary artery disease (CAD). Previous studies suggest a role of apoE as a modulator of immune response and inflammatory properties. We hypothesized that the presence of apo E4 is associated with an increased inflammatory burden in subjects with CAD as compared to subjects without CAD. METHODS:ApoE genotypes, systemic (C-reactive protein [CRP], fibrinogen, serum amyloid-A [SAA]) and vascular inflammatory markers (Lipoprotein-associated phospholipase A(2) [Lp-PLA(2)] and pentraxin-3 [PTX-3]) were assessed in 324 Caucasians and 208 African Americans, undergoing coronary angiography. RESULTS: For both ethnic groups, Lp-PLA(2) index, an integrated measure of Lp-PLA(2) mass and activity, increased significantly and stepwise across apoE isoforms (P = 0.009 and P = 0.026 for African Americans and Caucasians respectively). No differences were found for other inflammatory markers tested (CRP, fibrinogen, SAA and PTX-3). For the top cardiovascular score tertile, apo E4 carriers had a significantly higher level of Lp-PLA(2) index in both ethnic groups (P = 0.027 and P = 0.010, respectively). CONCLUSION: The presence of the apo E4 isoform was associated with a higher level of Lp-PLA(2) index, a marker of vascular inflammation. Our results suggest that genetic variation at the apoE locus may impact cardiovascular disease risk through enhanced vascular inflammation. Published by Elsevier Ireland Ltd.
Authors: Vasilios G Saougos; Afroditi P Tambaki; Mihalis Kalogirou; Michael Kostapanos; Irene F Gazi; Robert L Wolfert; Moses Elisaf; Alexandros D Tselepis Journal: Arterioscler Thromb Vasc Biol Date: 2007-07-26 Impact factor: 8.311
Authors: Jacquelyn Y Taylor; Aldi T Kraja; Lisa de Las Fuentes; Ansley Grimes Stanfill; Ashley Clark; Ann Cashion Journal: J Nurs Scholarsh Date: 2013-01-31 Impact factor: 3.176
Authors: Benjamin M Kandel; Brian B Avants; James C Gee; Corey T McMillan; Guray Erus; Jimit Doshi; Christos Davatzikos; David A Wolk Journal: Alzheimers Dement (Amst) Date: 2016-04-07
Authors: Gillian Coughlan; Ryan Larsen; Min Kim; David White; Rachel Gillings; Michael Irvine; Andrew Scholey; Neal Cohen; Cristina Legido-Quigley; Michael Hornberger; Anne-Marie Minihane Journal: Brain Commun Date: 2021-05-11