OBJECTIVE: Remission is rapidly becoming a key end point in rheumatoid arthritis (RA) clinical trials, but its definition is not satisfactory. Although it is generally believed that achieving a state of remission will lead to better structural outcome, this has not been studied systematically. As part of an undertaking to redefine remission, the current review describes the relationship between remission and long-term structural outcome. METHODS: A systematic literature search of PubMed, EMBase, and The Cochrane Library intersected 3 groups of terms: RA, remission, and long-term outcome. The search identified 1,138 records, of which 14 were relevant to the research question. RESULTS: All of the studies included in this review showed a relationship between remission and long-term structural damage or disability. Patients that achieved a state of remission, defined in various ways, showed less deterioration of function and radiographic progression compared with patients who did not reach a state of remission. CONCLUSION: Patients who achieved a state of remission were less likely to show deterioration of function and radiographic progression compared with patients who did not reach a state of remission.
OBJECTIVE: Remission is rapidly becoming a key end point in rheumatoid arthritis (RA) clinical trials, but its definition is not satisfactory. Although it is generally believed that achieving a state of remission will lead to better structural outcome, this has not been studied systematically. As part of an undertaking to redefine remission, the current review describes the relationship between remission and long-term structural outcome. METHODS: A systematic literature search of PubMed, EMBase, and The Cochrane Library intersected 3 groups of terms: RA, remission, and long-term outcome. The search identified 1,138 records, of which 14 were relevant to the research question. RESULTS: All of the studies included in this review showed a relationship between remission and long-term structural damage or disability. Patients that achieved a state of remission, defined in various ways, showed less deterioration of function and radiographic progression compared with patients who did not reach a state of remission. CONCLUSION:Patients who achieved a state of remission were less likely to show deterioration of function and radiographic progression compared with patients who did not reach a state of remission.
Authors: Josef S Smolen; Andre Beaulieu; Andrea Rubbert-Roth; Cesar Ramos-Remus; Josef Rovensky; Emma Alecock; Thasia Woodworth; Rieke Alten Journal: Lancet Date: 2008-03-22 Impact factor: 79.321
Authors: L H D van Tuyl; W F Lems; A E Voskuyl; P J S M Kerstens; P Garnero; B A C Dijkmans; M Boers Journal: Ann Rheum Dis Date: 2008-07-14 Impact factor: 19.103
Authors: T A Stamm; D Aletaha; S Pflugbeil; T Kapral; K Montag; K P Machold; J S Smolen Journal: Clin Exp Rheumatol Date: 2007 Nov-Dec Impact factor: 4.473
Authors: J S Smolen; C Han; D M F M van der Heijde; P Emery; J M Bathon; E Keystone; R N Maini; J R Kalden; D Aletaha; D Baker; J Han; M Bala; E W St Clair Journal: Ann Rheum Dis Date: 2008-07-01 Impact factor: 19.103
Authors: Paul Emery; Ferdinand C Breedveld; Stephen Hall; Patrick Durez; David J Chang; Deborah Robertson; Amitabh Singh; Ronald D Pedersen; Andrew S Koenig; Bruce Freundlich Journal: Lancet Date: 2008-07-16 Impact factor: 79.321
Authors: Tuulikki Sokka; Merete Lund Hetland; Heidi Mäkinen; Hannu Kautiainen; Kim Hørslev-Petersen; Reijo K Luukkainen; Bernard Combe; Humeira Badsha; Alexandros A Drosos; Joe Devlin; Gianfranco Ferraccioli; Alessia Morelli; Monique Hoekstra; Maria Majdan; Stefan Sadkiewicz; Miguel Belmonte; Ann-Carin Holmqvist; Ernest Choy; Gerd R Burmester; Recep Tunc; Aleksander Dimić; Jovan Nedović; Aleksandra Stanković; Martin Bergman; Sergio Toloza; Theodore Pincus Journal: Arthritis Rheum Date: 2008-09
Authors: D van der Heijde; L Klareskog; R Landewé; G A W Bruyn; A Cantagrel; P Durez; G Herrero-Beaumont; Y Molad; C Codreanu; G Valentini; R Zahora; R Pedersen; D MacPeek; J Wajdula; S Fatenejad Journal: Arthritis Rheum Date: 2007-12
Authors: A K Brown; P G Conaghan; Z Karim; M A Quinn; K Ikeda; C G Peterfy; E Hensor; R J Wakefield; P J O'Connor; P Emery Journal: Arthritis Rheum Date: 2008-10
Authors: P Emery; E Keystone; H P Tony; A Cantagrel; R van Vollenhoven; A Sanchez; E Alecock; J Lee; J Kremer Journal: Ann Rheum Dis Date: 2008-07-14 Impact factor: 19.103
Authors: Eugenio de Miguel; Angela Pecondón-Español; Manuel Castaño-Sánchez; Alfonso Corrales; Ricardo Gutierrez-Polo; Manuel Rodriguez-Gomez; Jose A Pinto-Tasende; Jose L Rivas; José Ivorra-Cortés Journal: Rheumatol Int Date: 2017-04-07 Impact factor: 2.631
Authors: David T Felson; Josef S Smolen; George Wells; Bin Zhang; Lilian H D van Tuyl; Julia Funovits; Daniel Aletaha; Cornelia F Allaart; Joan Bathon; Stefano Bombardieri; Peter Brooks; Andrew Brown; Marco Matucci-Cerinic; Hyon Choi; Bernard Combe; Maarten de Wit; Maxime Dougados; Paul Emery; Daniel Furst; Juan Gomez-Reino; Gillian Hawker; Edward Keystone; Dinesh Khanna; John Kirwan; Tore K Kvien; Robert Landewé; Joachim Listing; Kaleb Michaud; Emilio Martin-Mola; Pamela Montie; Theodore Pincus; Pamela Richards; Jeffrey N Siegel; Lee S Simon; Tuulikki Sokka; Vibeke Strand; Peter Tugwell; Alan Tyndall; Desirée van der Heijde; Suzan Verstappen; Barbara White; Frederick Wolfe; Angela Zink; Maarten Boers Journal: Arthritis Rheum Date: 2011-03