Literature DB >> 20189813

Chemical biology studies on norrisolide.

Gianni Guizzunti1, Thomas P Brady2, Derek Fischer2, Vivek Malhotra1, Emmanuel A Theodorakis2.   

Abstract

The cellular activity of norrisolide (7), a novel Golgi-vesiculating agent, was dissected as function of its chemical structure. This natural product induces irreversible vesiculation of the Golgi membranes and blocks protein transport at the level of the Golgi. The Golgi localization and fragmentation effects of 7 depend on the presence of the perhydroindane core, while the irreversibility of fragmentation depends on the acetyl group of 7. We show that fluorescent derivatives of norrisolide are able to localize to the Golgi apparatus and represent important tools for the study of the Golgi structure and function. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20189813      PMCID： PMC2838712          DOI： 10.1016/j.bmc.2010.02.007

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  56 in total

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