BACKGROUND AND PURPOSE: The relation between health-related quality of life (HRQOL) and survival was investigated at baseline and 6 months in 80 patients with advanced oral or oropharyngeal cancer after microvascular reconstructive surgery and (almost all) adjuvant radiotherapy. MATERIALS AND METHODS: Multivariate Cox regression analyses of overall and disease-specific survival were performed including sociodemographic (age, gender, marital status, comorbidity), and clinical (tumor stage and site, radical surgical, metastasis, radiotherapy) parameters, and HRQOL (EORTC QLQ-C30 global quality of life scale). RESULTS: Before treatment, younger age and having a partner were predictors of disease-specific survival; younger age predicted overall survival. At 6 months post-treatment, disease-specific and overall survival was predicted by (deterioration of) global quality of life solely. Global health-related quality of life after treatment was mainly influenced by emotional functioning. CONCLUSION: Deterioration of global quality of life after treatment is an independent predictor of survival in patients with advanced oral or oropharyngeal cancer.
BACKGROUND AND PURPOSE: The relation between health-related quality of life (HRQOL) and survival was investigated at baseline and 6 months in 80 patients with advanced oral or oropharyngeal cancer after microvascular reconstructive surgery and (almost all) adjuvant radiotherapy. MATERIALS AND METHODS: Multivariate Cox regression analyses of overall and disease-specific survival were performed including sociodemographic (age, gender, marital status, comorbidity), and clinical (tumor stage and site, radical surgical, metastasis, radiotherapy) parameters, and HRQOL (EORTC QLQ-C30 global quality of life scale). RESULTS: Before treatment, younger age and having a partner were predictors of disease-specific survival; younger age predicted overall survival. At 6 months post-treatment, disease-specific and overall survival was predicted by (deterioration of) global quality of life solely. Global health-related quality of life after treatment was mainly influenced by emotional functioning. CONCLUSION: Deterioration of global quality of life after treatment is an independent predictor of survival in patients with advanced oral or oropharyngeal cancer.
Authors: Luciana Lastrucci; Silvia Bertocci; Vittorio Bini; Simona Borghesi; Roberta De Majo; Andrea Rampini; Paola Pernici; Pietro Giovanni Gennari Journal: Radiol Med Date: 2017-01-09 Impact factor: 3.469
Authors: Ronald C Eldridge; Stephanie L Pugh; Andy Trotti; Kenneth Hu; Sharon Spencer; Sue S Yom; David Rosenthal; Nancy Read; Anand Desai; Elizabeth Gore; George Shenouda; Mark V Mishra; Deborah Bruner; Canhua Xiao Journal: Head Neck Date: 2019-08-22 Impact factor: 3.147
Authors: Annette J van Nieuwenhuizen; Laurien M Buffart; Jan H Smit; Ruud H Brakenhoff; Boudewijn J M Braakhuis; Remco de Bree; C René Leemans; Irma M Verdonck-de Leeuw Journal: Support Care Cancer Date: 2014-08-12 Impact factor: 3.603
Authors: L Putten; R Bree; P A Doornaert; J Buter; S E J Eerenstein; D H F Rietveld; D J Kuik; C R Leemans Journal: Acta Otorhinolaryngol Ital Date: 2015-06 Impact factor: 2.124