Chan Joo Yang1, Jong-Lyel Roh2, Min-Ju Kim3, Sang-wook Lee4, Sung-Bae Kim5, Seung-Ho Choi1, Soon Yuhl Nam1, Sang Yoon Kim1,6. 1. Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Republic of Korea. 2. Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 138-736, Republic of Korea. rohjl@amc.seoul.kr. 3. Department of Clinical Epidemiology and Biostatistics, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Republic of Korea. 4. Department of Radiation Oncology, Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Republic of Korea. 5. Department of Internal Medicine (Oncology), Asan Medical Centre, University of Ulsan College of Medicine, Seoul, Republic of Korea. 6. Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea.
Abstract
PURPOSE: Quality of life (QOL) scores in cancer patients are associated with disease course and treatment outcomes. The aim of this study was to prospectively evaluate the associations between pretreatment QOL scores and survival or functional outcomes in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: This prospective study enrolled a total of 141 patients with previously untreated HNSCC who underwent curative treatments from October 2010 to March 2012. Patients completed questionnaires on QOL including the European Organization of Research and Treatment of Cancer 30-item Core QOL questionnaire (EORTC QLQ-C30) and EORTC QOL questionnaire Head and Neck Cancer module (QLQ-H&N35). Univariate and multivariate analyses were used to identify QOL scores significantly associated with overall survival (OS), disease-free survival (DFS), and functional outcomes of gastrostomy or tracheostomy dependence. RESULTS: The 2-year OS and DFS rates were 82.3 and 78.0%, respectively. The rates of gastrostomy and tracheostomy dependence were 9.2 and 14.9%, respectively. After controlling for clinical factors, specific QOL indices of 'dyspnea' (hazard ratio 1.023 [95% confidence interval 1.006-1.039]) and 'appetite loss' (1.020 [1.005-1.034]) were significantly associated with OS, while 'insomnia' (1.013 [1.002-1.025]) and 'appetite loss' (1.014 [1.001-1.026]) scores were significantly predictive of DFS (P < 0.05). Global health status score (0.967 [0.935-1.000]) and fatigue (1.048 [1.010-1.086]) were significantly associated with the dependence of tracheostomy (P < 0.05). There was no relationship between gastrostomy dependence and QOL indices. CONCLUSION: This study provides evidence of significant relationships between certain pretreatment QOL measures and survival or functional outcomes in HNSCC patients.
PURPOSE: Quality of life (QOL) scores in cancerpatients are associated with disease course and treatment outcomes. The aim of this study was to prospectively evaluate the associations between pretreatment QOL scores and survival or functional outcomes in patients with head and neck squamous cell carcinoma (HNSCC). METHODS: This prospective study enrolled a total of 141 patients with previously untreated HNSCC who underwent curative treatments from October 2010 to March 2012. Patients completed questionnaires on QOL including the European Organization of Research and Treatment of Cancer 30-item Core QOL questionnaire (EORTC QLQ-C30) and EORTC QOL questionnaire Head and Neck Cancer module (QLQ-H&N35). Univariate and multivariate analyses were used to identify QOL scores significantly associated with overall survival (OS), disease-free survival (DFS), and functional outcomes of gastrostomy or tracheostomy dependence. RESULTS: The 2-year OS and DFS rates were 82.3 and 78.0%, respectively. The rates of gastrostomy and tracheostomy dependence were 9.2 and 14.9%, respectively. After controlling for clinical factors, specific QOL indices of 'dyspnea' (hazard ratio 1.023 [95% confidence interval 1.006-1.039]) and 'appetite loss' (1.020 [1.005-1.034]) were significantly associated with OS, while 'insomnia' (1.013 [1.002-1.025]) and 'appetite loss' (1.014 [1.001-1.026]) scores were significantly predictive of DFS (P < 0.05). Global health status score (0.967 [0.935-1.000]) and fatigue (1.048 [1.010-1.086]) were significantly associated with the dependence of tracheostomy (P < 0.05). There was no relationship between gastrostomy dependence and QOL indices. CONCLUSION: This study provides evidence of significant relationships between certain pretreatment QOL measures and survival or functional outcomes in HNSCC patients.
Entities:
Keywords:
Functional outcome; Head and neck squamous cell carcinoma; Prediction; Quality of life; Survival
Authors: James C Coyne; Thomas F Pajak; Jonathan Harris; Andre Konski; Benjamin Movsas; Kian Ang; Deborah Watkins Bruner Journal: Cancer Date: 2007-12-01 Impact factor: 6.860
Authors: Carrie A Karvonen-Gutierrez; David L Ronis; Karen E Fowler; Jeffrey E Terrell; Stephen B Gruber; Sonia A Duffy Journal: J Clin Oncol Date: 2008-06-01 Impact factor: 44.544
Authors: Joshua R Niska; Michele Y Halyard; Angelina D Tan; Pamela J Atherton; Samir H Patel; Jeff A Sloan Journal: Qual Life Res Date: 2017-02-28 Impact factor: 4.147
Authors: S Wiegand; V Zebralla; C Hammermüller; A Hinz; A Dietz; G Wichmann; M Pirlich; T Berger; K Zimmermann; T Neumuth; A Mehnert-Theuerkauf Journal: BMC Cancer Date: 2021-01-22 Impact factor: 4.430
Authors: A J van Nieuwenhuizen; L M Buffart; J A Langendijk; M R Vergeer; J Voortman; C R Leemans; I M Verdonck-de Leeuw Journal: Qual Life Res Date: 2020-12-08 Impact factor: 4.147