OBJECTIVE: Early detection of glycosaminoglycan (GAG) loss may provide insight into mechanisms of cartilage damage in the anterior cruciate ligament (ACL)-injured patient. We hypothesized that tibial and femoral Delayed Gadolinium-Enhanced MR Imaging of Cartilage (dGEMRIC) indices would be lower in the medial compartment of the ACL-injured knee than in the contralateral, uninjured knee, and that scan order (i.e., whether the injured or the uninjured knee was imaged first) would not affect the indices. METHODS: 15 subjects with unilateral ACL injuries received a double dose of gadolinium [Gd(DTPA)(2-)] intravenously. After 90 min, both knees were sequentially imaged. The injured knee was scanned first in the odd-numbered subjects and second in the even-numbered subjects. The dGEMRIC indices of the median slice of the medial compartment were determined using the MRIMapper software. Index comparisons were made between knee status (ACL-injured vs uninjured), scan order (ACL-injured first vs uninjured first), and cartilage location (tibia vs femur) using a mixed model. RESULTS: There was a significant difference in the mean dGEMRIC indices of the medial compartment between injured and uninjured knees (P<0.007). On average, there was a 13% decrease in the dGEMRIC index of the injured knee compared to the uninjured knee. There were no significant effects due to test order (P=0.800) or cartilage location (P=0.439). CONCLUSIONS: The results demonstrate lower GAG concentrations in the medial compartment of the femoral and tibial articular cartilage of the ACL-injured knee when compared to the contralateral uninjured knee. The dGEMRIC indices were not sensitive to scan order; thus, sequential imaging of both knees is possible in this patient population. Copyright 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
OBJECTIVE: Early detection of glycosaminoglycan (GAG) loss may provide insight into mechanisms of cartilage damage in the anterior cruciate ligament (ACL)-injured patient. We hypothesized that tibial and femoral Delayed Gadolinium-Enhanced MR Imaging of Cartilage (dGEMRIC) indices would be lower in the medial compartment of the ACL-injured knee than in the contralateral, uninjured knee, and that scan order (i.e., whether the injured or the uninjured knee was imaged first) would not affect the indices. METHODS: 15 subjects with unilateral ACL injuries received a double dose of gadolinium [Gd(DTPA)(2-)] intravenously. After 90 min, both knees were sequentially imaged. The injured knee was scanned first in the odd-numbered subjects and second in the even-numbered subjects. The dGEMRIC indices of the median slice of the medial compartment were determined using the MRIMapper software. Index comparisons were made between knee status (ACL-injured vs uninjured), scan order (ACL-injured first vs uninjured first), and cartilage location (tibia vs femur) using a mixed model. RESULTS: There was a significant difference in the mean dGEMRIC indices of the medial compartment between injured and uninjured knees (P<0.007). On average, there was a 13% decrease in the dGEMRIC index of the injured knee compared to the uninjured knee. There were no significant effects due to test order (P=0.800) or cartilage location (P=0.439). CONCLUSIONS: The results demonstrate lower GAG concentrations in the medial compartment of the femoral and tibial articular cartilage of the ACL-injured knee when compared to the contralateral uninjured knee. The dGEMRIC indices were not sensitive to scan order; thus, sequential imaging of both knees is possible in this patient population. Copyright 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
Authors: Guoan Li; Jeremy M Moses; Ramprasad Papannagari; Neil P Pathare; Louis E DeFrate; Thomas J Gill Journal: J Bone Joint Surg Am Date: 2006-08 Impact factor: 5.284
Authors: Christopher C Kaeding; Angela D Pedroza; Richard D Parker; Kurt P Spindler; Eric C McCarty; Jack T Andrish Journal: Arthroscopy Date: 2005-04 Impact factor: 4.772
Authors: R B Frobell; H P Roos; E M Roos; M-P Hellio Le Graverand; R Buck; J Tamez-Pena; S Totterman; T Boegard; L S Lohmander Journal: Osteoarthritis Cartilage Date: 2008-02-21 Impact factor: 6.576
Authors: C M Haslauer; K A Elsaid; B C Fleming; B L Proffen; V M Johnson; M M Murray Journal: Osteoarthritis Cartilage Date: 2013-09-13 Impact factor: 6.576
Authors: G M Utturkar; L A Irribarra; K A Taylor; C E Spritzer; D C Taylor; W E Garrett; Louis E Defrate Journal: Ann Biomed Eng Date: 2012-08-02 Impact factor: 3.934
Authors: Adrián Guerra-González; Carmen da Casa; Íñigo Crespo; David Pescador; Lorena Benito-Garzón; Juan F Blanco Journal: Histol Histopathol Date: 2021-11-02 Impact factor: 2.303