Literature DB >> 20188578

Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.

Pritam Thapa1, Radha Karki1, Hoyoung Choi1, Jae Hun Choi1, Minho Yun1, Byeong-Seon Jeong1, Mi-Ja Jung2, Jung Min Nam2, Younghwa Na3, Won-Jea Cho4, Youngjoo Kwon2, Eung-Seok Lee1.   

Abstract

A series of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives were designed, synthesized, and evaluated for their topoisomerase I and II inhibition and cytotoxic activity against several human cancer cell lines. Compounds 10-19 showed moderate topoisomerase I and II inhibitory activity and 20-29 showed significant topoisomerase II inhibitory activity. Structure-activity relationship study revealed that 4-(5-chlorofuran-2-yl)-2-(thiophen-3-yl) moiety has an important role in displaying topoisomerase II inhibition. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20188578     DOI： 10.1016/j.bmc.2010.01.065

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  6 in total

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Journal:  Mol Divers       Date:  2013-11       Impact factor: 2.943

2.  Design and development of topoisomerase inhibitors using molecular modelling studies.

Authors:  Muthu K Kathiravan; Madhavi M Khilare; Aparna S Chothe; Madhuri A Nagras
Journal:  J Chem Biol       Date:  2012-09-29

3.  Synthesis of 4-aryl-6-indolylpyridine-3-carbonitriles and evaluation of their antiproliferative activity.

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Journal:  Tetrahedron Lett       Date:  2014-02-05       Impact factor: 2.415

4.  Synthesis, Molecular Docking Study, and Cytotoxicity Evaluation of Some Novel 1,3,4-Thiadiazole as Well as 1,3-Thiazole Derivatives Bearing a Pyridine Moiety.

Authors:  Amr S Abouzied; Jehan Y Al-Humaidi; Abdulrahman S Bazaid; Husam Qanash; Naif K Binsaleh; Abdulwahab Alamri; Sheikh Muhammad Ibrahim; Sobhi M Gomha
Journal:  Molecules       Date:  2022-09-27       Impact factor: 4.927

5.  Approaches towards the synthesis of a novel class of 2-amino-5-arylazonicotinate, pyridazinone and pyrido[2,3-d]pyrimidine derivatives as potent antimicrobial agents.

Authors:  Hamada Mohamed Ibrahim; Haider Behbehani; Mohamed H Elnagdi
Journal:  Chem Cent J       Date:  2013-07-17       Impact factor: 4.215

6.  Facile synthesis and antiproliferative activity of new 3-cyanopyridines.

Authors:  Hassan M Abdel-Aziz; Sobhi M Gomha; Abdelaziz A El-Sayed; Yahia Nasser Mabkhot; Abdulrhman Alsayari; Abdullatif Bin Muhsinah
Journal:  BMC Chem       Date:  2019-12-28
  6 in total

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