Hyoun-Ah Kim1, Ja-Young Jeon, Jeong-Moon Yoon, Chang-Hee Suh. 1. BK21 Division of Cell Transformation and Restoration, Department of Allergy and Rheumatology, Ajou University School of Medicine, Youngtong-gu, Suwon, Korea.
Abstract
BACKGROUND: To investigate the clinical significance of beta2-microglobulin in Korean patients with systemic lupus erythematosus (SLE). METHODS: Blood samples were collected from patients with SLE (n = 100) and normal healthy controls (n = 50). The level of beta2-microglobulin was investigated by enzyme-linked immunosorbent assay. Serial samples from SLE patients were collected at 4.2 +/- 2.6 months after first sampling. RESULTS: The beta2-microglobulin levels of the SLE patients (2.64 +/- 0.11 microg/mL) were higher than the normal controls (2.14 +/- 0.04 microg/mL, P < 0.001). The patients with SLE with serositis, oral ulcer, or lupus nephritis had significantly higher beta2-microglobulin levels than those without, respectively. A significant correlation was found between the beta2-microglobulin level and each of anti-dsDNA antibody, hemoglobin, complement, and SLE Disease Activity Index. In sequential sampling of patients with SLE, a positive correlation was found between the change of the SLE Disease Activity Index and the change of the beta2-microglobulin levels. CONCLUSIONS: These data suggest that the measurement of beta2-microglobulin seem to be a useful addition to the laboratory tests that can help in assessment of disease activity of SLE.
BACKGROUND: To investigate the clinical significance of beta2-microglobulin in Korean patients with systemic lupus erythematosus (SLE). METHODS: Blood samples were collected from patients with SLE (n = 100) and normal healthy controls (n = 50). The level of beta2-microglobulin was investigated by enzyme-linked immunosorbent assay. Serial samples from SLEpatients were collected at 4.2 +/- 2.6 months after first sampling. RESULTS: The beta2-microglobulin levels of the SLEpatients (2.64 +/- 0.11 microg/mL) were higher than the normal controls (2.14 +/- 0.04 microg/mL, P < 0.001). The patients with SLE with serositis, oral ulcer, or lupus nephritis had significantly higher beta2-microglobulin levels than those without, respectively. A significant correlation was found between the beta2-microglobulin level and each of anti-dsDNA antibody, hemoglobin, complement, and SLE Disease Activity Index. In sequential sampling of patients with SLE, a positive correlation was found between the change of the SLE Disease Activity Index and the change of the beta2-microglobulin levels. CONCLUSIONS: These data suggest that the measurement of beta2-microglobulin seem to be a useful addition to the laboratory tests that can help in assessment of disease activity of SLE.
Authors: Christopher C Silliman; Monika Dzieciatkowska; Ernest E Moore; Marguerite R Kelher; Anirban Banerjee; Xiayuan Liang; Kevin J Land; Kirk C Hansen Journal: Transfusion Date: 2011-08-31 Impact factor: 3.157
Authors: Marcus Vinicius Madureira Silva; Grace T Moscoso-Solorzano; Sonia K Nishida; Gianna Mastroianni-Kirsztajn Journal: Nephron Extra Date: 2012-06-22