Literature DB >> 201845

Protein-DNA and protein-hormone interactions in prealbumin: a model of the thyroid hormone nuclear receptor?

C C Blake, S J Oatley.   

Abstract

High resolution X-ray analysis of the hormone-binding protein prealbumin has shown that it has a structural complementarity to double-helical DNA. The proposed binding site is composed of two symmetry-related beta-sheets containing a pair of helically disposed arms, which can interact with the bases in the wide groove of DNA. A palindromic target sequence is indicated by the symmetry of the protein. The two identical thyroid hormone binding sites on prealbumin are located in a channel that runs completely through the molecule. These two structural features suggest prealbumin as a model for the thyroid hormone nuclear receptor, providing a number of detailed predictions of its properties.

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Year:  1977        PMID： 201845     DOI： 10.1038/268115a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  32 in total

1.  Regulation of activity of chromatin receptors for thyroid hormone: possible involvement of histone-like proteins.

Authors:  N L Eberhardt; J C Ring; L K Johnson; K R Latham; J W Apriletti; R N Kitsis; J D Baxter
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

2.  Transport of maternal transthyretin to the fetus in the viviparous teleost Neoditrema ransonnetii (Perciformes, Embiotocidae).

Authors:  Osamu Nakamura; Rintaro Suzuki; Kotaro Asai; Harunobu Kaji; Takuya Kaneko; Yo Takahashi; Ayaka Takahagi; Shigeyuki Tsutsui
Journal:  J Comp Physiol B       Date:  2020-01-24       Impact factor: 2.200

3.  Molecular conformation of a peptide fragment of transthyretin in an amyloid fibril.

Authors:  Christopher P Jaroniec; Cait E MacPhee; Nathan S Astrof; Christopher M Dobson; Robert G Griffin
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-12       Impact factor: 11.205

Review 4.  The supramolecular chemistry of β-sheets.

Authors:  Pin-Nan Cheng; Johnny D Pham; James S Nowick
Journal:  J Am Chem Soc       Date:  2013-04-02       Impact factor: 15.419

Review 5.  The molecular basis of thyroid hormone action.

Authors:  L J DeGroot; A Nakai; A Sakurai; E Macchia
Journal:  J Endocrinol Invest       Date:  1989-12       Impact factor: 4.256

6.  A computer aided oligonucleotide analysis provides a model sequence for RNA polymerase-promoter recognition in E.coli.

Authors:  G E Scherer; M D Walkinshaw; S Arnott
Journal:  Nucleic Acids Res       Date:  1978-10       Impact factor: 16.971

7.  Support for the multigenic hypothesis of amyloidosis: the binding stoichiometry of retinol-binding protein, vitamin A, and thyroid hormone influences transthyretin amyloidogenicity in vitro.

Authors:  J T White; J W Kelly
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-30       Impact factor: 11.205

Review 8.  The transmissible amyloidoses: genetical control of spontaneous generation of infectious amyloid proteins by nucleation of configurational change in host precursors: kuru-CJD-GSS-scrapie-BSE.

Authors:  D C Gajdusek
Journal:  Eur J Epidemiol       Date:  1991-09       Impact factor: 8.082

9.  The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation?

Authors:  Kerensa Broersen; Frederic Rousseau; Joost Schymkowitz
Journal:  Alzheimers Res Ther       Date:  2010-07-14       Impact factor: 6.982

Review 10.  Spontaneous generation of infectious nucleating amyloids in the transmissible and nontransmissible cerebral amyloidoses.

Authors:  D C Gajdusek
Journal:  Mol Neurobiol       Date:  1994-02       Impact factor: 5.590
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