| Literature DB >> 20182347 |
Gabriela Gualco1, Lawrence M Weiss, Carlos E Bacchi.
Abstract
MUM1/IRF4 protein is a member of the interferon regulatory factor (IRF) family of transcriptional factors initially described as downstream regulators of interferon signaling. The quantity of this factor varies within the hematopoietic system in a lineage and stage-specific way. It is considered to be a key regulator of several steps in lymphoid, myeloid, and dendritic cell differentiation and maturation. MUM1/IRF4 expression is observed in many lymphoid and myeloid malignancies, and may be a promising target for the treatment of some of these neoplasms. We reviewed the literature on MUM1/IRF4, with emphasis on the pathologic aspects of this marker in reactive and malignant hematologic and nonhematologic conditions.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20182347 DOI： 10.1097/PAI.0b013e3181cf1126
Source DB: PubMed Journal: Appl Immunohistochem Mol Morphol ISSN： 1533-4058