BACKGROUND: Statins are widely prescribed to patients with atherosclerosis. A retrospective database analysis was used to examine the role of preoperative statin use in hospital mortality, for patients undergoing isolated coronary artery bypass grafting (CABG.) METHODS: The study population comprised 2377 patients who had isolated CABG at Allegheny General Hospital between 2000 and 2004. Mean age of the patients was 65 +/- 11 years (range 27 to 92 years). 1594 (67%) were male, 5% had previous open heart procedures, and 4% had emergency surgery. 1004 patients (42%) were being treated with a statin at the time of admission. Univariate, bivariate (Chi2, Fisher's Exact and Student's t-tests) and multivariate (stepwise linear regression) analyses were used to evaluate the association of statin use with mortality following CABG. RESULTS: Annual prevalence of preoperative statin use was similar over the study period and averaged 40%. Preoperative clinical risk assessment demonstrated a 2% risk of mortality in both the statin and non-statin groups. Operative mortality was 2.4% for all patients, 1.7% for statin users and 2.8% for non-statin users (p < 0.07). Using multivariate analysis, lack of statin use was found to be an independent predictor of mortality in high-risk patients (n = 245, 12.9% vs. 5.6%, p < 0.05). CONCLUSIONS: Between 2000 and 2004 less than 50% of patients at this institution were receiving statins before admission for isolated CABG. A retrospective analysis of this cohort provides evidence that preoperative statin use is associated with lower operative mortality in high-risk patients.
BACKGROUND: Statins are widely prescribed to patients with atherosclerosis. A retrospective database analysis was used to examine the role of preoperative statin use in hospital mortality, for patients undergoing isolated coronary artery bypass grafting (CABG.) METHODS: The study population comprised 2377 patients who had isolated CABG at Allegheny General Hospital between 2000 and 2004. Mean age of the patients was 65 +/- 11 years (range 27 to 92 years). 1594 (67%) were male, 5% had previous open heart procedures, and 4% had emergency surgery. 1004 patients (42%) were being treated with a statin at the time of admission. Univariate, bivariate (Chi2, Fisher's Exact and Student's t-tests) and multivariate (stepwise linear regression) analyses were used to evaluate the association of statin use with mortality following CABG. RESULTS: Annual prevalence of preoperative statin use was similar over the study period and averaged 40%. Preoperative clinical risk assessment demonstrated a 2% risk of mortality in both the statin and non-statin groups. Operative mortality was 2.4% for all patients, 1.7% for statin users and 2.8% for non-statin users (p < 0.07). Using multivariate analysis, lack of statin use was found to be an independent predictor of mortality in high-risk patients (n = 245, 12.9% vs. 5.6%, p < 0.05). CONCLUSIONS: Between 2000 and 2004 less than 50% of patients at this institution were receiving statins before admission for isolated CABG. A retrospective analysis of this cohort provides evidence that preoperative statin use is associated with lower operative mortality in high-risk patients.
Authors: Leslie L Clark; John S Ikonomidis; Fred A Crawford; Arthur Crumbley; John M Kratz; Martha R Stroud; Robert F Woolson; James J Bruce; Joyce S Nicholas; Daniel T Lackland; Michael R Zile; Francis G Spinale Journal: J Thorac Cardiovasc Surg Date: 2006-03 Impact factor: 5.209
Authors: Charles D Collard; Simon C Body; Stanton K Shernan; Shirley Wang; Dennis T Mangano Journal: J Thorac Cardiovasc Surg Date: 2006-08 Impact factor: 5.209
Authors: M V Podgoreanu; W D White; R W Morris; J P Mathew; M Stafford-Smith; I J Welsby; H P Grocott; C A Milano; M F Newman; D A Schwinn Journal: Circulation Date: 2006-07-04 Impact factor: 29.690
Authors: J A Magovern; T Sakert; G J Magovern; D H Benckart; J A Burkholder; G A Liebler; G J Magovern Journal: J Am Coll Cardiol Date: 1996-11-01 Impact factor: 24.094
Authors: John C Bonano; Ashley K Aratani; Tanmaya D Sambare; Stuart B Goodman; James I Huddleston; William J Maloney; David R Burk; Alistair J Aaronson; Andrea K Finlay; Derek F Amanatullah Journal: J Arthroplasty Date: 2021-05-25 Impact factor: 4.757