Literature DB >> 20179820

DNA in nanochannels--directly visualizing genomic information.

Fredrik Persson1, Jonas O Tegenfeldt.   

Abstract

The power of nanofluidic channels to analyze DNA is described along with practical experimental hints. As an introduction, a general overview is given on conventional DNA analysis tools, as well as tools under development towards the $1000 genome. The focus of this tutorial review is the stretching of DNA in nanoscale channels for coarse-grained mapping of DNA. To understand the behavior of the DNA, basic theory is discussed. Experimental details are revealed so that the reader, with the proper equipment, should be able to perform experiments. Basic approaches to the analysis of the data are discussed. Finally, potential future directions are discussed including the application of melting mapping as a simple barcode for the DNA.

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Year:  2010        PMID： 20179820     DOI： 10.1039/b912918a

Source DB:  PubMed          Journal:  Chem Soc Rev        ISSN： 0306-0012            Impact factor:   54.564


  48 in total

1.  Surface charge, electroosmotic flow and DNA extension in chemically modified thermoplastic nanoslits and nanochannels.

Authors:  Franklin I Uba; Swathi R Pullagurla; Nichanun Sirasunthorn; Jiahao Wu; Sunggook Park; Rattikan Chantiwas; Yoon-Kyoung Cho; Heungjoo Shin; Steven A Soper
Journal:  Analyst       Date:  2015-01-07       Impact factor: 4.616

2.  Fluctuation modes of nanoconfined DNA.

Authors:  Alena Karpusenko; Joshua H Carpenter; Chunda Zhou; Shuang Fang Lim; Junhan Pan; Robert Riehn
Journal:  J Appl Phys       Date:  2012-01-17       Impact factor: 2.546

3.  Wafer-scale fabrication of high-aspect ratio nanochannels based on edge-lithography technique.

Authors:  Quan Xie; Qing Zhou; Fei Xie; Jianming Sang; Wei Wang; Haixia Alice Zhang; Wengang Wu; Zhihong Li
Journal:  Biomicrofluidics       Date:  2012-02-09       Impact factor: 2.800

Review 4.  Nanotechnologies for biomedical science and translational medicine.

Authors:  James R Heath
Journal:  Proc Natl Acad Sci U S A       Date:  2015-11-24       Impact factor: 11.205

5.  High throughput fabrication of disposable nanofluidic lab-on-chip devices for single molecule studies.

Authors:  Jeroen A van Kan; Ce Zhang; Piravi Perumal Malar; Johan R C van der Maarel
Journal:  Biomicrofluidics       Date:  2012-07-30       Impact factor: 2.800

6.  Modeling the relaxation time of DNA confined in a nanochannel.

Authors:  Douglas R Tree; Yanwei Wang; Kevin D Dorfman
Journal:  Biomicrofluidics       Date:  2013-10-22       Impact factor: 2.800

7.  Hydrodynamics of DNA confined in nanoslits and nanochannels.

Authors:  Kevin D Dorfman; Damini Gupta; Aashish Jain; Abhiram Muralidhar; Douglas R Tree
Journal:  Eur Phys J Spec Top       Date:  2014-12-01       Impact factor: 2.707

8.  Interplay between chain stiffness and excluded volume of semiflexible polymers confined in nanochannels.

Authors:  Abhiram Muralidhar; Douglas R Tree; Yanwei Wang; Kevin D Dorfman
Journal:  J Chem Phys       Date:  2014-02-28       Impact factor: 3.488

9.  Mixed confinement regimes during equilibrium confinement spectroscopy of DNA.

Authors:  Damini Gupta; Julian Sheats; Abhiram Muralidhar; Jeremy J Miller; Derek E Huang; Sara Mahshid; Kevin D Dorfman; Walter Reisner
Journal:  J Chem Phys       Date:  2014-06-07       Impact factor: 3.488

10.  PrgB promotes aggregation, biofilm formation, and conjugation through DNA binding and compaction.

Authors:  Andreas Schmitt; Kai Jiang; Martha I Camacho; Venkateswara Rao Jonna; Anders Hofer; Fredrik Westerlund; Peter J Christie; Ronnie P-A Berntsson
Journal:  Mol Microbiol       Date:  2018-07-31       Impact factor: 3.501
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